Invasive Solid Mucinous Papillary Carcinoma Breast with Neuroendocrine Differentiation: A Case Report with Immunohistochemical Study

  • Jyoti Mishra Department of Pathology, School of Medical Sciences and Research, Sharda Hospital, Greater Noida, Uttar Pradesh.
  • Srijan Srivastav Department of Pathology Lady Hardinge Medical College, New Delhi
  • Natasha Singh Department of Pathology, School of Medical Sciences and Research, Sharda Hospital, Greater Noida, Uttar Pradesh
  • Varun Prasad Department of Anaesthesia, School of Medical Sciences and Research, Sharda Hospital, Greater Noida, Uttar Pradesh
DOI: https://doi.org/10.21276/apalm.2877
Keywords: Invasive Solid Papillary carcinoma, neuroendocrine, mucin, immunohistochemistry

Abstract

Solid papillary carcinoma of the breast (SPCB) is a distinctive form of papillary carcinoma that tends to occur in older women and usually has a favorable prognosis. We describe an invasive solid papillary carcinoma with extracellular and intracellular mucin and neuroendocrine differentiation in a 60-year old female. The cytological features have been also been highlighted with an insight on differentials that were helpful in its correct identification preoperatively.

References

1. Sakuma T, Mori M, Nonogaki I. Fine-needle aspiration cytology of solid papillary carcinoma of the breast. Diagn Cytopathol. 2020; 48(1):53-6.
2. Wong SI, Cheung H, Tse GM. Fine Needle Aspiration Cytology of Invasive Micropapillary Carcinoma of the Breast. A Case Report Acta Cytol Nov-Dec 2000; 44(6):1085-9.
3. Maluf HM, Koerner FC. Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. Am. J. Surg. Pathol. 1995; 19:1237-44.
4. Saremian J, Rosa M. Solid Papillary Carcinoma of the Breast A Pathologically and Clinically Distinct Breast Tumor. Arch Pathol Lab Med. 2012; 136:1308-11.
5. Guo S, Wang Y, Rohr J, Fan C, Li Q, Li X, Wang Z. Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. Breast 2016, 26:67-72.
6. Otsuki Y, Yamada M, Shimizu S, et al. Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int. 2007;57(7):421–429.
7. Weigelt B, Geyer FC, Horlings HM, Kreike B, Halfwerk H, Reis-Filho JS. Mucinous and neuroendocrine breast carcinomas of no special type. Mod Pathol. 2009; 22:1401–14.
8. Nassar H, Qureshi H, Adsoy NV, Visscher D. Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. Am J Surg Pathol. 2006; 30:501-7.
9. Moritani S, Ichihara S, Kushima R, Okabe H, Bamba M, Kobayashi TK, et al. Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with usual ductal hyperplasia. Virchows Arch. 2007; 450:539-47.
10. Şenel F, Karaman H, Eroglu M, Tuna O. Invasive papillary breast carcinoma, solid variant with neuroendocrine differentiation. Turk J Surg. 2017; 33(4): 302-4.
11. Rosen PP, ed. Rosen's Breast Pathology. 4th ed. Philadelphia, PA: LWW; 2014:433-7.
12. Ellis I, Allison K, Brogi E, B Fox Stephen. The 2019 WHO classification of tumours of the breast.
13. Gunduz M, Iscan Y, Erbil Y et al. Neuroendocrine differentiated breast carcinoma: a case report. J Breast Health 2009;5(4):225-7.
14. Nawawi O,Goh K Y, Rahmat K.A rare case of infiltrating primary neuroendocrine
carcinoma of the breast. Iran J Radiol 2012; 9(4):212-6.
15. Xue Lin, Yoshiaki Matsumoto, Tomomi Nakakimura, Kazuo Ono. Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review. Surg Case Rep. 2020 Dec; 6: 143.
Published
2020-09-25
Issue
Vol 7 No 9 (2020)
Section
Case Report

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