Polymorphous Adenocarcinoma of Lacrimal Gland: A Rare Case Report

  • Md Ali Osama Department of Histopathology, Sir Ganga Ram Hospital, New Delhi, India
  • Seema Rao Department of Histopathology, Sir Ganga Ram Hospital, New Delhi, India
  • A K Grover Department of Ophthalmology, Sir Ganga Ram Hospital, New Delhi, India
DOI: https://doi.org/10.21276/apalm.3079
Keywords: Immunohistochemistry, Lacrimal gland, Polymorphous adenocarcinoma

Abstract

Polymorphous adenocarcinoma is a slow growing malignant tumor of minor salivary glands. The most common location of these tumors is palate, buccal mucosa, upper lip, floor of mouth and retromolar region. This malignant neoplasm is characterized by cytological uniformity, architectural diversity and infiltrative growth pattern. This is a case report of polymorphous adenocarcinoma occurring in lacrimal gland. They are seldom reported in this location and propose unique diagnostic challenges.

References

Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004;111:997-1008.

Seethala RR, Stenman G. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017;11:55-67.

Freedman PD, Lumerman H. Lobular carcinoma of intraoral minor salivary gland origin. Report of twelve cases. Oral Surg Oral Med Oral Pathol. 1983;56:157-66.

Evans HL, Batsakis JG. Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. Cancer. 1984;53:935-42.

Kimple AJ, Austin GK, Shah RN, et al. Polymorphous low-grade adenocarcinoma: a case series and determination of recurrence. Laryngoscope. 2014;124:2714-9.

Castle JT, Thompson LD, Frommelt RA, Wenig BM, Kessler HP. Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. Cancer. 1999;86:207-19.

Selva D, Davis GJ, Dodd T, Rootman J. Polymorphous low-grade adenocarcinoma of the lacrimal gland. Arch Ophthalmol. 2004;122:915-7.

Ni C, Kuo PK, Dryja TP. Histopathological classification of 272 primary epithelial tumors of the lacrimal gland. Chin Med J (Engl). 1992;105:481-5.

Darling MR, Schneider JW, Phillips VM. Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers. Oral Oncol. 2002;38:641-5.

Meer S, Altini M. CK7+/CK20- immunoexpression profile is typical of salivary gland neoplasia. Histopathology. 2007;51:26-32.

Perez-Ordonez B, Linkov I, Huvos AG. Polymorphous low-grade adenocarcinoma of minor salivary glands: a study of 17 cases with emphasis on cell differentiation. Histopathology. 1998;32:521-9.

Verdijk RM, Pecorella I, Mooy CM. The Orbit, Including the Lacrimal Gland and Lacrimal Drainage System. In: Heegaard S., Grossniklaus H. (eds) Eye Pathology. Springer, Berlin, Heidelberg;2015.p.547-731.

Chatura KR. Polymorphous low grade adenocarcinoma. J Oral Maxillofac Pathol. 2015;19:77-82.

Published
2021-08-30
Issue
Vol 8 No 8 (2021)
Section
Case Report

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).