Cytomorphological Study of Hepatic Lesions by FNAC
AbstractIntroduction: Fine Needle Aspiration Cytology (FNAC) is a simple, safe, very low-cost and rapid procedure for diagnostic purpose which makes surgical intervention and exploratory laparotomy unnecessary. The introduction of modern diagnostic imaging techniques, mainly ultrasonography (USG) and Computerized Tomography (CT), has enabled the detection and location of lesions in sites such as liver, which are not easily accessible to surgical biopsies. Aim: To assess the utility of FNAC in the diagnosis of liver lesions. To study the cytomorphological features, age and sex distribution of liver lesions. Materials and methods: The study included 24 liver lesions which were detected clinically or radiologically. USG guided FNA was done in all cases. The smears were stained with Haematoxylin and eosin (H and E), May Grunwald Giemsa (MGG) and Papanicolaou’s stains. A cyto-histopathological correlation was done wherever possible. From the residual material, additional slides and cell blocks were prepared. Special stains were used whenever required. In doubtful cases immunohistochemistry (IHC) was done on formalin-fixed paraffin cell blocks and immunocytochemistry on conventional smears wherever necessary and possible. Results: All the lesions were found to be malignant. Out of 24 liver FNA cases, maximum lesions were seen in females and the affected age group for liver malignancies was 51-60 years. Out of 24 liver FNA cases, 20 cases were metastatic and 4 were primary cases. Among metastatic cases, maximum cases were of metastatic adenocarcinoma and the primary lesions of liver included all cases of hepatocellular carcinoma. Conclusion: Fine needle aspiration cytology of liver is a simple, safe, repeatable and rapid diagnostic procedure. In case of hepatic lesions, it is of outmost advantage in recognizing the nature of lesion i.e., primary, and metastatic as well as in early diagnosis of lesion so that patient can be treated as early as possible.
Kumar V, Abbas AK, Aster JC. Robbins basic pathology e-book. Elsevier Health Sciences; 2017 Mar 8.
Hemalatha AL, Sindhuram S, Sushma S, Suma JK, Varna I, Aditya A. Ultrasound Guided Fnac of Abdominal–Pelvic Masses-The Pathologists’ Perspective. Journal of Clinical and Diagnostic Research: JCDR. 2013 Feb;7(2):273.
Andola SK, Sidhalingreddy, Sainath K. Andola, Fine needle aspiration cytology. J Clin Diagnostic Res. 2011;5(3):551–8.
Nigam SK, Paliwal U, Nigam N. Role of fine needle aspiration cytology in the diagnosis of intra-abdominal lumps. Journal of Evolution of Medical and Dental Sciences. 2014 Mar 3;3(9):2395-403.
Suva CM. Study of Image Guided FNAC in Intra-abdominal Mass Lesions at tertiary care hospital, Jamnagar, Gujarat, India. Ind J Basic Appl Med Res. 2016;6(1):40-51.
Konjengbam R, Huidrom N, Akoijam NJ, Sorokhaibam BD. Ultrasonography and computed tomography guided fine needle aspiration cytology in diagnosing intra-abdominal lesions-a 6-year retrospective study in a tertiary care hospital in manipur. Liver.;70:54.
Glaxon JA, Saldanha P, Vasudevan S. Utility of Usg-Guided Fine Needle Aspiration Cytology in. Annals of Pathology and Laboratory Medicine. 2018 May;5(5).
Philipose CS, Amin AN, C S J. Computed Tomography And Ultrasound Guided Fine Needle Aspiration Cytology In The Diagnosis Of Intraabdominal And Pelvic Lesions. Ann Pathol Lab Med. 2018;5(9):A754-758.
Zeisel J. Diagnostic Evaluation Studies. Sociol Archit Des. 2018;(1):39–46.
Meena SP, Patangia P, Rai NN. Diagnostic utility of USG-guided FNAC in hepatic lesions. J. Evid. Based Med. Healthc. 2016;3(52):2699-702.
K. J, J. Cytology of Malignant Lesions of Liver: An Institutional Study. Indian J Pathol Res Pract. 2017;6(2(Part-1)):282–7.
Verma N, Neetu., Sharma SP, Singh P, Kumar A. Role of ultrasound guided fine needle aspiration cytology of right hypochondrial masses. Int J Res Med Sci. 2017;5(12):5312.
Asghar F, Riaz S. Diagnostic accuracy of percutaneous cytodiagnosis of hepatic masses, by ultrasound guided fine needle aspiration cytology. Annals of King Edward Medical University. 2010;16(3):184-.
Copyright (c) 2022 Jahnavi Nilay Vyas, Prashant R Patel, Krutika Patel, Vasudha M Bhagat
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).