Solid Papillary Carcinoma: A Clinicopathological Evaluation of a Rare Variant of Carcinoma Breast
Abstract
Background: Solid papillary carcinoma (SPC) of the breast is considered a low grade carcinoma with a favorable prognosis. We aimed to describe clinicopathologic features including immunohistochemistry expression profile and to delineate adverse prognostic features, if any. Methods: Patients diagnosed with SPC between the years 2016–2022 were retrospectively identified from the archives at Kailash Cancer Hospital and Research Centre, Goraj. Microscopic slides and clinical history were reviewed. Immunohistochemical stains were performed. Results: Of 12 SPCs cases retrieved, 11 (92%) were associated with ductal carcinoma in situ (DCIS). The median tumour size was 1.6cm (range 1.3-7.0cm). All tumors were positive for hormone receptor expression and negative for HER-2Neu. 6 cases (50%) show neuroendocrine differentiation. Lymph node involvement was identified in 4/12 (33.3%) patients. Of 12 patients with outcome data (median follow-up 30 months, range 7-72 months), none (0%) developed local recurrence. No distant metastasis or deaths were observed. Conclusions: SPCs has excellent prognosis with no local recurrence or distant metastasis in this study. Axillary node metastasis is found to be associated with larger tumor size, however it appears to have no impact on disease free or overall survival.References
Clement, Zachariah VK. 2017. "Solid papillary carcinoma of breast: A review." International journal of surgery and medicine 57-59.
Zhong, D.R., Sun, P.P., and Liang, Z.Y. Clinicopathological features of solid papillary carcinoma in breast. J Diag Path.2010;17: 165–168.
Rakha EA, Ahmed MA, Ellis IO. Papillary carcinoma of the breast: diagnostic agreement and management implications.Histopathology. 2016;69(5):862-870.
Mulligan AM, O’Malley FP. Papillary lesions of the breast: a review. Adv Anat Pathol. 2007 Mar; 14(2):108–19.
Collins LC, Schnitt SJ. Papillary lesions of the breast: selected diagnostic and management issues. Histopathology. 2008 Jan; 52(1):20–9.
Ueng SH, Mezzetti T, Tavassoli FA. Papillary neoplasms of the breast: a review. Arch Pathol Lab Med. 2009 Jun; 133(6):893–907.
Pal, Sumanta. 2010. "Papillary Carcinoma of the Breast: An Overview." Breast Cancer Research and Treatment 637-645.
Saremian J, Rosa M. Solid Papillary Carcinoma of the Breast: A Pathologically and Clinically Distinct Breast Tumour, Arch Pathol Lab Med 2012;136:1308-1311.7).
Rakha EA, Gandhi N, Climent F, et al. Encapsulated papillary carcinoma of the breast: an invasive tumor with excellent prognosis. Am J Surg Pathol. 2011;35:1093-1103
Guo S, Wang Y, Rohr J, et al. Solid papillary carcinoma of the breast: A special entity needs to be distinguished from conventional invasive carcinoma avoiding over-treatment. Breast. 2016;36: 67-72.
Leena JB, Kini RG, Amber S. Invasive Solid papillary carcinoma of the breast: A report of two cases. J Clin Diagn Res 2013; 7(6):1150-1151.
Nassar H, Qureshi H, Adsay NV, et al. Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. Am J Surg Pathol. 2006;30:501-507.
Oh EJ, Koo JS, Kim JY, et al. Correlation between solid papillary carcinoma and associated invasive carcinoma according to expression of WT1 and several MUCs. Pathol Res Pract. 2014; 210:953-958
Maluf HM, Koerner FC. Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. Am J Surg Pathol. 1995 Nov; 19(11):1237–44.
Leena J.B,Reshma Kini, Safeena Amber. Invasive (solid) papillary carcinoma of breast: A report of two cases. Journal of Clinical and Diagnostic Research. 2013 June, Vol-7(6): 1150-1151
Jinous Saremian, Merilin Rosa. Solid papillary carcinoma of breast, A pathologically and clinically distinct breast tumor. Arch Pathol Lab Med October 2012 136; 1308-1311.
Sarah Morgan et al. Solid papillary carcinoma and encapsulated papillary carcinoma of the breast: Clinical-Pathological features and basement membrane studies of 50 cases. Pathobiology 2021;88:359–373
Tan PH, Schnitt SJ, van de Vijver MJ, Ellis IO, Lakhani SR. Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology. 2015 May; 66(6): 761–70.
Otsuki Y, Yamada M, Shimizu S, Suwa K, Yoshida M, Tanioka F, et al. Solid-papillary carcinoma of the breast: clinicopathological study of 20 cases. Pathol Int. 2007 Jul; 57(7): 421–9
Wei S. Papillary lesions of the breast: an update. Arch Pathol Lab Med. 2016 Jul; 140(7): 628–43.
Inno A, Bogina G, Turazza M, et al. Neuroendocrine Carcinoma of the Breast: Current Evidence and Future Perspectives. Oncologist. 2016;21:28-32.
Board WCoTE. WHO classification of tumours of the breast. Lyon, France: International Agency for Research on Cancer (IARC); 2019.
Copyright (c) 2022 Dhruvi Neel Shah, Yogesh Mistry, Bhawana Chaudhry, Rakshit Shah
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