E-Cadherin Expression in Endometrial Carcinoma

  • Geethika P Ullas Department of Pathology, Government Medical College Trivandrum
  • Sheela K M Department of Pathology, Government Medical College Trivandrum
Keywords: Endometrial carcinoma, E-cadherin expression, histological subtypes, Stage, Grade


Background In this study, we wanted to determine the proportion of negative E-cadherin expression in endometrial carcinoma cases received in the Department of Pathology and evaluate the E-cadherin expression in different histological subtypes of endometrial carcinoma. Methods This was a cross-sectional study conducted over one year in the Department of Pathology, Government Medical College, Thiruvananthapuram, Kerala. 52 specimens histopathologically diagnosed as endometrial carcinoma in the Department of Pathology, were studied. Age, histological subtype, grade, stage and E-cadherin staining were recorded. Data were entered into an Excel sheet and analysed with SPSS. Result Clinicopathological features of were studied and the median age group of the patients was between         51-60 years. The majority of cases were of  endometrioid type and presented at stage IA (69.2 %). Negative  E cadherin expression was seen more commonly in Type II endometrial carcinomas (50 & 33.3 % of serous and clear cell carcinoma respectively). Among the Type I carcinoma, grade 3 tumours showed the most proportion of negative E-cadherin staining pattern (33.3 %). Conclusion: The study concluded that most of the tumours occurred in the postmenopausal age group and the majority of cases were in stage IA, most cases were of endometrioid type. E-cadherin was lost most commonly in high-grade endometrioid carcinoma and Type 2 carcinomas. Among the 3 grades of endometrioid carcinoma, grade 3 (33.3 %) had the highest proportion of negative staining and grade 1 had the highest proportion of positive staining characteristics. (57.1 %).


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Original Article