High Grade Appendiceal Mucinous Neoplasm Presenting as Intussusception In an Elderly Female-A Case Report

  • Manjari SKVSK Pathology, GSL Medical College and General Hospital
  • Mark Ruth Prasanna Pathology, GSL Medical College and General Hospital
  • T Satya Prakash Venkatachalam Pathology, GSL Medical College and General Hospital
Keywords: Appendiceal mucinous tumors, intussusception, high grade, AMN, HAMN


Introduction: Appendiceal mucinous neoplasms (AMNs) are rare and account for 1% of gastrointestinal neoplasms and the diagnosis is mostly incidental. In spite of advances in the understanding of AMNs and their association with peritoneal disease, AMNs are still confusing entities in respect to their diagnosis and treatment alike. Case Report: We report a case of a 51year old female who presented with abdominal pain  and vomiting and was diagnosed as ileo-colic intussusception on ultrasonography and CECT abdomen. Histopathological examination of right hemicolectomy specimen revealed a high grade appendicular mucinous neoplasm with low grade areas. The peri-appendiceal mucin deposition forming a mass in the cecum at the base of appendix was the lead point for intussusception in this case. No features of pseudomyxoma peritonei was seen in this case. This patient is well after 18 months of follow up period. Conclusion: Appendiceal mucinous neoplasms are rare and diagnosis is often difficult as presentation is mostly non-specific. Hence, awareness and further classification of these tumours is essential for diagnosis, determining the risk of recurrence and malignancy and also prognostication.


Ramaswamy V. Pathology of Mucinous Appendiceal Tumors and Pseudomyxoma Peritonei. Indian J Surg Oncol. 2016;7:258-267.

Nutu OA, Marcacuzco Quinto AA, Manrique Municio A, et al. Mucinous appendiceal neoplasms: Incidence, diagnosis and surgical treatment. Cir Esp. 2017;95(6):321-327.

S.H. Tirumani. M. Fraser-Hill, R. Auer et al., “Mucinous neoplasms of the appendix : a current comprehensive clinicopathologic and imaging review,” Cancer Imaging.2013;13(1):14-25.

Siddiqui G, Lipka S, Freedman L, Takeshige U, Rizvon K, Mustacchia P. Mucinous adenocarcinoma of the appendix presenting as intussusception in 27 year old Female. J Gastrointestinal Oncol. 2012;3(4):369-372.

Gonzalez RS, Carr NJ, Liao H, Pai RK, Vulaj D A, et al. High grade appendiceal mucinous neoplasm. Clinicopathologic findings in 35 cases. Arch Pathol Lab Med.2022;4(30)1-8.

Rhonda Y, Jinru S, David S, Hejin H, Robert OD. Prognostic significance of localised extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J of Surgical Path. 2019;33(2):248-255.

Chirca A, Negreanu L,Iliesiu A, Costea R. Mucinous appendiceal neoplasm: A case report. World J Clin Cases.2021;9(7):1728-33.

Umetsu SE, Shafizadeh N, Kakar S. Grading and staging mucinous neoplasms of the appendix: a case series and review of the literature. Hum Pathol.2017;69:81-89.

Case Report