Incidence Of Hemoglobinopathies In South Indian Population – 4 Year Study
Keywords:
Anemia, Hemoglobinopathy, South India, Thalassemia
Abstract
Background Hemoglobinopathies are very common, but majority being asymptomatic it is under diagnosed. Hemoglobinopathies are important health care threat in tropical countries. The present study analyzed the incidence of hemoglobinpathies in south Indian population reported in regional laboratory in Chennai catering Tamil nadu and Andhra Pradesh population. Methods A cohort of samples which was received for abnormal hemoglobinopathy studies for evaluation of anemia and prenatal screening from Tamil nadu and Andrapradesh population for 4 years was analyzed using capillary electrophoresis method in (Sebia Minicap instrument) for incidence of hemoglobinopathies. Result Total number of cases studied during 4 years (2018-2022) is 17678, Of which 1194(7%) were detected with hemoglobinopathy/ abnormal hemoglobin variant. Of which 56.28% were female and 43.72% were male. Common age group under study is 21-30(30.07%). Beta thalassemia trait was detected at the highest frequency (69.13%) followed by HbE-Beta thalaseemia(6.87%) and least being HbD homozygous. Conclusion Our study analyzed a cohort and reported a spectrum of hemoglobin variants and its incidence in Tamil nadu and Andhrapradesh population.References
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2. Sinha S, Black ML, Agarwal S, et al. Profiling -thalassaemia mutations in India at state and regional levels: implications for genetic education, screening and counseling programmes. Hugo J. 2009;3:51–62.
3. Verma IC, Saxena R, Kohli S. Hemoglobinopathies in India—Clinical and Laboratory Aspects.
4. Iyer S, Sakhare S, Sengupta C, Velumani A. Hemoglobinopathy in India.
5. Surjawan Y, Tan HL, Setiabudy RD, Rositawati W. Early Screening of Hemoglobinopathy in Indonesia Using Erythrocyte Indices.
6. Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann N Y Acad Sci. 1998;850:251–69.
7. Verma IC, Saxena R, Kohli S. Hemoglobinopathies in India—Clinical and Laboratory Aspects.
8. Frequency of β-thalassemia trait and other hemoglobinopathies in Northern & Western India. Indian J Hum Genet. 2010 Mar;16(1):16-25.
9. Sood SK, Madan N, Colah R, et al. Collaborative study on thalassemia. Report of ICMR Task Force study on thalassemia. New Delhi: Indian Council of Medical Research; 1993.
10. Mohanty D, Colah R, Gorakshakar. Jai Vigyan S&T Mission Project on community control of thalassemia syndromes—Awareness, screening, genetic counseling and prevention. New Delhi: Indian Council of Medical Research; 2008.
11. Dolai TK, Dutta S, Bhattacharyya M, et al. Prevalence of Hemoglobinopathies in rural Bengal, India. Hemoglobin. 2012;36:57–63.
12. Serjeant GR. The case for dedicated sickle cell centres. Indian J Hum Genet. 2006; 12:148–51.
13. De M, Halder A, Podder S, et al. Anemia and hemoglobinopathies in tribal population of eastern and north eastern India. Hematology. 2006;11:371–3.
14. Ray GK, Jena RK. Spectrum of Hemoglobinopathies: A New Revelation in a Tertiary Care Hospital of Odisha.
15. Rangan A, Sharma P, Dadu T, et al. -Thalassemia mutations in subjects with borderline HbA(2) values: a pilot study in North India. Clin Chem Lab Med. 2011;49: 2069–72.
16. Thomas E, et al. Regional distribution of -thalassemia mutations in India. Hum Genet. 1997;100:109–13.
17. Russo G, De Franceschi L, Colombatti R, et al. Current challenges in the management of patients with sickle cell disease – A report of the Italian experience. Orphanet J Rare Dis. 2019;14:120.
18. Russo-Mancuso G, La Spina M, Schilirò G. The changing profile of sickle cell disease in Italy. Eur J Epidemiol. 2003;18:923–4.
Published
27-08-2023
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