A Rare Case of Epithelial-Myoepithelial Carcinoma Breast in A Young Female with HER2neu Positivity
Abstract
Epithelial-myoepithelial tumors of breast are biphasic neoplasms, with dual participation of epithelial and myoepithelial components. It is a very rare tumor, common in elderly females. EMC breast resembles its salivary gland counterpart, which itself forms less than 1% of all salivary gland tumors. Herein, we report one such rare case of EMC breast in a young female with aberrant HER2 positivity, a feature not yet reported in literature.References
Zhai DY, Shi YW, Shao N, Zhen TT, Shi HJ, Zhang XL, et al. Malignant adenomyoepithelioma of the breast: Two case reports and review of the literature. World J Clin Cases. 2021;9(31):9549–56.
Sugano I, Nagao T, Tajima Y, Ishida Y, Nagao K, Ooeda Y, et al. Malignant adenomyoepithelioma of the breast: A non-tubular and matrix-producing variant. Pathol Int. 2001;51(3):193–9.
Kakkar A, Jangra K, Kumar N, Sharma MC, Mathur SR, Deo SVS. Epithelial-myoepithelial carcinoma of the breast: A rare type of malignant adenomyoepithelioma. Breast J. 2019;25(6):1273–5.
Balasopoulou A, Κokkinos P, Pagoulatos D, Plotas P, Makri OE, Georgakopoulos CD, et al. Symposium Recent advances and challenges in the management of retinoblastoma Globe .2017;17(1):1.
Baum JE, Sung KJ, Tran H, Song W, Ginter PS. Mammary Epithelial-Myoepithelial Carcinoma: Report of a Case With HRAS and PIK3CA Mutations by Next-Generation Sequencing. Int J Surg Pathol. 2019;27(4):441–5.
Zhu J, Li K, Dong X, Zhou P, Li P, Bi J. Metaplastic breast carcinoma composed of epithelial-myoepithelial carcinoma and squamous cell carcinoma: A case report. Med (United States). 2018;97(15):13–6.
Shah AK, Venkatesan S, Katoch R, Jaiswai SS, Gambhir RPS, Bhardwaj R. Epithelial-myoepithelial carcinoma ex pleomorphic adenoma in breast: An exotic rarity. Med J Armed Forces India [Internet]. 2011;67(1):74–6. Available from: http://dx.doi.org/10.1016/S0377-1237(11)80023-7
Petrozza V, Pasciuti G, Pacchiarotti A, Tomao F, Zoratto F, Rossi L, et al. Breast adenomyoepithelioma: A case report with malignant proliferation of epithelial and myoepithelial elements. World J Surg Oncol. 2013;11:2–7.
Tan PH, Ellis IO. Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: Updates from the WHO Classification of Tumours of the Breast 2012. J Clin Pathol. 2013;66(6):465–70.
Grenier K, Altinel G, Dastani Z, Omeroglu A. Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features. Case Rep Pathol. 2020;2020:1–4.
Hu M, Wang M. Breast Epithelial-myoepithelial Carcinoma With HER2 Gene Amplification : a Rare Case and Review of Literature. 2021;1–9.
Ali RH, Hayes MM. Combined Epithelial-Myoepithelial Lesions of the Breast. Surg Pathol Clin [Internet]. 2012;5(3):661–99. Available from: http://dx.doi.org/10.1016/j.path.2012.06.003
Zhang Z, Wang Y, Xie X, Peng J, Hong J, Bi L, et al. Malignant adenomyoepithelioma of the breast: A case report. Medicine (Baltimore). 2021;100(5):e24461.
Febres-Aldana CA, Mejia-Mejia O, Krishnamurthy K, Mesko T, Poppiti R. Malignant transformation in a breast adenomyoepithelioma caused by amplification of c-myc: A common pathway to cancer in a rare entity. J Breast Cancer. 2020;23(1):93–9.
Copyright (c) 2023 Shipra Verma, Bhupesh Guleria, Vrushali Raut, S Anand, Prerna Guleria, M S Tevatia
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
