Cytomorphological Spectrum of Orbital and Peri-orbital Lesions – A Retrospective Study from A Tertiary Care Center, Manipur, India
Abstract
Background Fine needle aspiration cytology (FNAC) is a reliable, safe and simple diagnostic technique which is being implemented in diagnosing palpable and/or visible lesions in the body. This study was conducted for evaluating the role of FNAC as a routine screening/diagnostic tool in a spectrum of orbital and periorbital lesions. The aim of this study was to evaluate the role of FNAC in orbital and periorbital lesions. Methods A hospital based cross-sectional study was conducted in the Cytology section, Department of Pathology, RIMS for a period of 10 years from April 2013 to May 2022. A total of 95 cases with orbital and periorbital lesions were inducted in the study through purposive sampling. FNAC procedure was done using 10cc/20cc syringe with 23G/22G needle with or without a Cameco handle. Slides were stained using MGG (May-Grunwald Giemsa) and Pap (Papanicolaou) stains followed by their microscopic examination. Demographic parameters such as age and gender as well as clinical parameters such as size, site and duration of the lesion were analyzed. Result The mean age of patients was found to be 33 years with a slight male predominance (54 patients; 56.84%). The adequacy of FNAC was 96.82%. Epidermal Inclusion Cyst (30 cases; 31.58%) was the commonest lesion. Five cases (5; 5.26%) were malignant on cytopathology. By applying Kappa statistics, a near perfect agreement (k=0.86) between FNAC and histopathology was observed, being statistically significant, p=0.01 (<0.05). Conclusion: In our study, a high concordance/agreement was observed for the neoplastic lesions, thereby establishing FNAC as a useful tool for screening as well as diagnosing orbital and periorbital lesions. It surrogates other invasive procedures, eliminating complications in nonresectable or inapproachable lesions.References
Solo S, Siddaraju N, Srinivasan R. Use of fine needle cytology in the diagnosis of orbital and eyelid mass lesions. Acta cytologica. 2009;53(1):41-52.
Dey PR, Radhika SR, Rajwanshi AR, Ray R, Nijhawan R, Das A. Fine needle aspiration biopsy of orbital and eyelid lesions. Acta cytologica. 1993 Nov 1;37(6):903-7.
Schyberg E. Fine needle aspiration biopsy of orbital tumours. Acta Ophthalmol (Copenh)(suppl). 1975;125:11-5.
Gupta S, Sood B, Gulati M, Takhtani D, Bapuraj R, Khandelwal N, Singh U, Rajwanshi A, Gupta S, Suri S. Orbital mass lesions: US-guided fine-needle aspiration biopsy—experience in 37 patients. Radiology. 1999 Nov;213(2):568-72.
Chowdhury Z, Sharma JD, Kakoti LM, Sarma A, Ahmed S, Hazarika M. Experience with orbital tumors from a tertiary cancer centre of north east India: a pathology perspective. Journal of Laboratory Physicians. 2020 Nov 23;12(03):171-7.
Orell SR, Sterrett GF. Orell, Orell and Sterrett's Fine Needle Aspiration Cytology E-Book: Expert Consult. Elsevier Health Sciences; 2011 Aug 9.
Koss LG, Melamed MR, editors. Koss' diagnostic cytology and its histopathologic bases. Lippincott Williams & Wilkins; 2018.
Gray W, Kocjan G. Diagnostic Cytopathology E-Book: Expert Consult: Online and Print. Elsevier Health Sciences; 2010 May 24.
Slater D, Barrett P, Durham C. Standards and datasets for reporting cancers Dataset for histopathological reporting of primary invasive cutaneous squamous cell carcinoma and regional lymph nodes February 2019 https://www. rcpath. org/uploads/assets/9c1d8f71-5d3b-4508-8e6200f11e1f4a39/Dataset-for-histopathological-reporting-of-primary-invasivecutaneous-squamous-cell-carcinoma-and-regional-lymph-nodes. pdf. Last access 20th July. 2020.
Slater D, Barrett P, Durham C. Standards and Datasets for Reporting Cancers Dataset for Histopathological Reporting of Primary Cutaneous Basal Cell Carcinoma. February 2019.
Glasgow BJ, Goldbert RA, Gordon LK. Fine needle aspiration of orbital masses. Ophthalmol Clin North Am. 1995;8:73-81.
Agrawal P, Dey P, Lal A. Fine‐needle aspiration cytology of orbital and eyelid lesions. Diagnostic cytopathology. 2013 Nov;41(11):1000-11.
Asadi Amoli F, Sadeghi Tarri A, Hamzeh Doost K, Kamalian N, Moradi Tabriz H. Comparison of the results of fine needle aspiration biopsy specimens and permanent histopathologic preparation in orbital mass lesions. Iranian Journal of Pathology. 2011 Jun 1;6(3):124-32.
Nair LK, Sankar S. Role of fine needle aspiration cytology in the diagnosis of orbital masses: a study of 41 cases. Journal of Cytology/Indian Academy of Cytologists. 2014 Apr;31(2):87.
Ashok Kumar P, Kalpana VM, Faraz Ali M et al. Study of role of fine needle aspiration cytology (FNAC) in eyelid and orbital lesions. J. Evid. Based Med. Healthc. 2016; 3(69), 3771-3774.
Khan L, Malukani K, Malaiya S, Yeshwante P, Ishrat S, Nandedkar SS. Role of fine needle aspiration cytology as a diagnostic tool in orbital and adnexal lesions. Journal of Ophthalmic & Vision Research. 2016 Jul;11(3):287.
Yousif M, Lu J, Frost A, Steele R, Salih ZT. Diagnostic Utility of Fine Needle Aspiration Cytology of the Orbit: A 26 Year Retrospective Study of a Single Institution’s Experience. J Cytol Histol. 2018;9(525):2.
Rastogi N, Gupta A. Fine needle cytology-diagnostic tool for palpable orbital and eyelid lesions. International Journal of Research in Medical Sciences. 2017 Jun;5(6):2592.
Arora R, Rewari R, Betharia SM. Fine needle aspiration cytology of orbital and adnexal masses. Acta cytologica. 1992 Jul 1;36(4):483-91.
Cangiarella JF, Cajigas A, Savala E, Elgert P, Slamovits TL, Suhrland MJ. Fine needle aspiration cytology of orbital masses. Acta cytologica. 1996 Nov 1;40(6):1205-11.
Gupta N, Kaur J, Rajwanshi A, Nijhawan R, Srinivasan R, Dey P, Singh U, Gupta P. Spectrum of orbital and ocular adnexal lesions: an analysis of 389 cases diagnosed by fine needle aspiration cytology. Diagnostic Cytopathology. 2012 Jul;40(7):582-5.
Font PL. Epithelial tumors of the lacrimal glands: An analysis of 265 cases. Ocular and adnexal tumors. 1978:787-805.
Glasgow BJ, Layfield LJ. Fine‐needle aspiration biopsy of orbital and periorbital masses. Diagnostic cytopathology. 1991 Mar;7(2):132-41.
Midena E, Segato T, Piermarocchi S, Boccato P. Fine needle aspiration biopsy in ophthalmology. Survey of ophthalmology. 1985 May 1;29(6):410-22.
Jakobiec FA, Coleman DJ, Chattock A, Smith M. Ultrasonically guided needle biopsy and cytologic diagnosis of solid intraocular tumors. Ophthalmology. 1979 Sep 1;86(9):1662-78.
Copyright (c) 2024 Yengkhom Daniel Singh, Gayatri Devi Pukhrambam, Rachel Shimray, Sharmila Laishram, Babina Sarangthem, Haobijam Persy; Ngamba Akham; Sushma Khuraijam
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
