Primary Pulmonary Choriocarcinoma in a male: a rare case report
Keywords:
Primary choriocarcinoma, Germ cell tumor, Extragonadal choriocarcinoma, β-HCG, Lung
Abstract
Primary Choriocarcinoma (PCC) most commonly occurs in the female genital tract following gestational events such as hydatidiform mole, normal pregnancy, abortion and ectopic pregnancy. The tumor also occurs in males. In males, choriocarcinoma occurs most often in the testes. Less frequently, these tumors have also been reported in other organs such as the urinary bladder, kidney, liver, stomach and colon. Metastasis to the lung is common, but PCC originating in the lung is extremely rare.The authors report a case of a 26-year-old male non-smoker who presented with respiratory distress and constitutional symptoms along with a large left lung mass and bilateral multiple pulmonary nodules. Clinical and imaging findings of testes and other organs were normal. Level of serum human chorionic gonadotrophin was markedly elevated and it raised the suspicion of primary pulmonary choriocarcinoma of the lung which was confirmed by trans-thoracic biopsy from the mass with immunohistochemistry. This is the third case from India occurring in a male.References
1) Collins DH, Pugh RC. Classification and fre-quency of testicular tumors. Br J Urol 1964;36:1–11.
2) Bokemeyer C, Nichols CR, Droz JP. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol 2002; 20:1864–73.
3) Cacciamani J. Case of choriocarcinoma of the lung. Clin Notes Respir Dis1971; 10: 10-11.
4) Hayakawa K, Takahashi M, Sasaki K, Kawaoit A, Okano T. Primary choriocarcinoma of the lung: case report of two male subjects. Acta Pathol Jpn1977; 27:123- 35.
5) Kalla AH, Voss EC Jr, Reed RJ 3rd. Primary choriocarcinoma of the lung (a case report). WV Med J 1980; 76: 261-3.
6) Zapatero J, Bellon J, Baamonde C, Aragoneses FG, Cubillo J, Orusco E et al. Primary choriocarcinoma of the lung: presentation of a case and review of the literature. Scand J Thorac Cardiovasc Surg1982; 16: 279-81.
7) Kuang XW. Primary pulmonary choriocarci-noma in a male: report of a case and review of the literature. Zhonghua Jie He He Hu Xi Xi Ji Bing Za Zhi1984; 383:354-5.
8) Sridhar KS, Saldana MJ, Thurer RJ, Beattie EJ. Primary choriocarcinoma of the lung: report of a case treated with intensive multimodality therapy and review of the literature. J Surg Oncol1989; 41: 93-7.
9) Vaideeswar P, Mehta J, Deshpande J. Primary pulmonary choriocarcinoma--a series of 7 cases. Indian J Pathol Microbiol. 2004; 47:494-6.
10) Fine G, Smith RWJr, Pachter MR. Primary extragenital choriocarcinoma in the male subject. Case report and review of the literature. Am J Med1962;32:776–94.
11) Sullivan LG. Primary choriocarcinoma of the lung in a man. Arch Pathol Lab Med1989; 113: 82-3.
12) Otsuka T, Ohshoima Y, Sunaga Y, Nagashima K. Primary pulmonary choriocarcinoma in a four month old boy complicated with precocious puberty. Acta Paediatr Jpn1994; 36: 404-7.
13) Durieu I, Berger N, Loire R, Gamondes JP, Guilaud PH, Cordier JF. Contralateral hemorrhagic pulmonary metastases (“choriocarcinoma syndrome”) after pneumonectomy for primary pulmonary choriocarcinoma. Thorax1994; 49: 523-4.
14) Toda S, Inoue Y, Ishino T, Yonemitsu N, Terayama K, Miyabara S et al. A rare case of primary pulmonary choriocarcinoma in a male: immunohistochemical detection for human chorionic gonadotrophin, epidermal growth factor (EGF) and ECF-receptor. Endocr J1995; 42: 655-9.
15) Canver CC, Voytovich MC. Resection of an unsuspected primary pulmonary choriocarcinoma. Ann Thorac Surg1996; 61: 1249-51.
16) Uwatoko K, Kajita M. Primary choriocarcinoma of the lung: a case report involving a male. J Jpn Assoc Chest Surg1997; 11: 662.
17) Ikura Y, Inoue T, Tsukuda H. Primary chori-ocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: are they independent entities? Histopathology 2000;36:17–25.
2) Bokemeyer C, Nichols CR, Droz JP. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol 2002; 20:1864–73.
3) Cacciamani J. Case of choriocarcinoma of the lung. Clin Notes Respir Dis1971; 10: 10-11.
4) Hayakawa K, Takahashi M, Sasaki K, Kawaoit A, Okano T. Primary choriocarcinoma of the lung: case report of two male subjects. Acta Pathol Jpn1977; 27:123- 35.
5) Kalla AH, Voss EC Jr, Reed RJ 3rd. Primary choriocarcinoma of the lung (a case report). WV Med J 1980; 76: 261-3.
6) Zapatero J, Bellon J, Baamonde C, Aragoneses FG, Cubillo J, Orusco E et al. Primary choriocarcinoma of the lung: presentation of a case and review of the literature. Scand J Thorac Cardiovasc Surg1982; 16: 279-81.
7) Kuang XW. Primary pulmonary choriocarci-noma in a male: report of a case and review of the literature. Zhonghua Jie He He Hu Xi Xi Ji Bing Za Zhi1984; 383:354-5.
8) Sridhar KS, Saldana MJ, Thurer RJ, Beattie EJ. Primary choriocarcinoma of the lung: report of a case treated with intensive multimodality therapy and review of the literature. J Surg Oncol1989; 41: 93-7.
9) Vaideeswar P, Mehta J, Deshpande J. Primary pulmonary choriocarcinoma--a series of 7 cases. Indian J Pathol Microbiol. 2004; 47:494-6.
10) Fine G, Smith RWJr, Pachter MR. Primary extragenital choriocarcinoma in the male subject. Case report and review of the literature. Am J Med1962;32:776–94.
11) Sullivan LG. Primary choriocarcinoma of the lung in a man. Arch Pathol Lab Med1989; 113: 82-3.
12) Otsuka T, Ohshoima Y, Sunaga Y, Nagashima K. Primary pulmonary choriocarcinoma in a four month old boy complicated with precocious puberty. Acta Paediatr Jpn1994; 36: 404-7.
13) Durieu I, Berger N, Loire R, Gamondes JP, Guilaud PH, Cordier JF. Contralateral hemorrhagic pulmonary metastases (“choriocarcinoma syndrome”) after pneumonectomy for primary pulmonary choriocarcinoma. Thorax1994; 49: 523-4.
14) Toda S, Inoue Y, Ishino T, Yonemitsu N, Terayama K, Miyabara S et al. A rare case of primary pulmonary choriocarcinoma in a male: immunohistochemical detection for human chorionic gonadotrophin, epidermal growth factor (EGF) and ECF-receptor. Endocr J1995; 42: 655-9.
15) Canver CC, Voytovich MC. Resection of an unsuspected primary pulmonary choriocarcinoma. Ann Thorac Surg1996; 61: 1249-51.
16) Uwatoko K, Kajita M. Primary choriocarcinoma of the lung: a case report involving a male. J Jpn Assoc Chest Surg1997; 11: 662.
17) Ikura Y, Inoue T, Tsukuda H. Primary chori-ocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung: are they independent entities? Histopathology 2000;36:17–25.
Published
2014-09-28
Section
Case Report
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).
