Dysfunctional Uterine Bleeding: A Clinico-Pathological Study at a Tertiary Care Centre

  • Ramesh B.H
  • Rajeshwari Karibasappa Kumbar Dr. Rajeshwari k Assistant professor Department of pathology Gulburga Institute of medical Sciences Gulburga
Keywords: Dysfunctional uterine bleeding, Proliferative phase endometrium, Menorrhagia.

Abstract

Background: Dysfunctional uterine bleeding (DUB) is a form of abnormal uterine bleeding and it is one of the most common presenting  complains  in gynecology outpatient department in all age groups.Aim and Objectives: The present study aimed to study the clinical features and various histological  patterns of endometrium  in DUB   and correlating histopathology of endometrium with clinical presentation in clinically diagnosed cases of DUB.Methods: Present study is a descriptive type of study conducted over 111 cases over a period of one year from June 2015- June 2016 in the department of pathology at a tertiary care centreResults: Majority of patients with DUB were in 3rd to 4th decade (40.35%) and were multiparous (93.3%). Of the 111 cases, 51.35% of cases showed histological features associated with DUB. Menorrhagia was the most frequent presenting complaint (56.14%) followed by metrorrhagia in 14.04%. Proliferative phase (50.88%) was the most common endometrial pattern seen with DUB cases in age group from 21-50 years. Endometrial hyperplasia occurred between the age group of 30-50years.Conclusion: Menorrhagia is the most common presenting complaint with proliferative phase endometrium.  Age has definite influence on endometrial histology. Histopathology remains the gold standard method of diagnosis of DUB and its types and to exclude the local causes, so as to plan the accurate management in DUB patients.  DOI: 10.21276/APALM.1169

References

1. Algotar KM, Nalawade A. Physiology of menstruation. In:
Purandare CN editor: Dysfunctional uterine bleeding -An
update. JAYPEE: New Delhi; 2004;1-15.
2. Kumar P, Malhotra N, editors. Abnormal and excessive
uterinebleeding. Jeffcoate’s Principal of Gynecology. 7th
ed. New Delhi: JAYPEE;2008;598-616.
3. Davey DA. Dysfunctional uterine bleeding. In: Whitfield CR
editor: Dewhurst’s textbook of Obstetrics and Gynecology
for postgraduates. 4th ed. London: Blackwell science;
1995;624-45.
4. Katuwal N ,Gurung G,Rana A,Jha A. A clinicopathological
study of dysfunctional uterine bleeding.Journal of Pathology
of Nepal. 2014;4:635- 38.
5. Munro MG.Abnormal uterine bleeding in the reproductive
years. J Am Assoc Gynecol Laparoscop.1999;6:391-428.
6. Ash SJ, Farrell SA, Flowerden G. Endometrial biopsy in
DUB. J Reprod Med.1996;41:892–896.
7. Fraser IS.Treatment of ovulatory and anovulatory
dysfunctional uterine bleeding with oral progestogens.Aust
NZ J Obstet Gynecol.1990;30:353-6
8. Emanuel MH, Verdel MJ, Wamsteker K, Lannes FB.A
prospective comparison of transvaginal ultrasonography
and diagnostic hysteroscopy in the evaluation of patients
with abnormal uterine bleeding.Am J Obstet Gynecol
1995;172:547-52.
9. Purandare S, Jhalam L. Pathological picture in Hysterectomy
done for abnormal uterine bleeding. J Obstet Gynaecol
India. 1993;43:418-21.
10. Pilli GS, Sethi B, Dhaded AV , Mathur PR. Dysfunctional
Uterine Bleeding-Study of 100 cases .J Obstet Gynaecol
India 2002;52(3):87-9.
11. Shergill SK, Shergill HK, Gupta M, Kaur S.
Clinicopathological Study of Hysterectomies. JIMA.
2002;100(4):238-9.
12. Patel SR, Sheth MS, Rawal MY. Dysfunctional Uterine
Bleeding- Place of Hysterectomy in its Management. J
Postgrad. 1986;32(3):150-3.
13. Sucheta KL,Mallikarjuna M,Madhu KP,Arun BJ,Niranjan
N.Hysterectomy:Clinical profile,indications and
postoperative complications.Int J Reprod Contracept Obstet
Gynecol.2016 Jul;5(7):2093-96.
14. Dass A, Chugh S. Dysfunctional Uterine Bleeding: A clinic-
pathological study. J Obstet Gynaecol India. 1964;14:34854.
15. Bhattacharji SK. Dysfunctional uterine hemorrhage:
correlation of endometrial pattern with clinical behavior. J
Obstet Gynaecol India. 1964;14:372-9.
16. Ghosh BK, Sengupta KP. A study of the endometrium and
cystohormonal pattern in functional uterine bleeding. J
Obstet Gynaeol India.1968;310-6.
17. Mehrotra VG, Mukerjee K, Pandey M, Samanth V.
Functional uterine bleeding -A review of 150 cases. J Obstet
Gynaecol India. 1972;22:684-9.
18. Joshi SK, Deshapande DH. Clinico - pathological study in
274 cases of dysfunctional uterine hemorrhage. J Obstet
Gynaecol India.1964;14:360-71.
19. Muzaffar M, Akhtar K, Yasmin S, Rehman M, Iqbal W,
Khan M. Menstrual irregularities with excessive blood
loss: a Clinico- Pathological correlation. J Pak Med Assoc
2005;55:1-4.
20. Bhosle A, Fonseca M. Evaluation and histopathological
correlation of Abnormal uterine bleeding in Perimenopausal
women. Bombay Hospital J 2010;52:69-72.
21. Samal S, Gupta U, Agarwal P, Samal N. Clinico- pathological
Study of Dysfunctional Uterine Bleeding in Postmenopausal
Women. J Obstet Gynaecol India. 2000;50(6):100-1.
Published
2017-08-31
Issue
Vol 4 No 4 (2017)
Section
Original Article

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