Evaluation of pattern of angiogenesis in various menstrual disorders in different district in Gujarat, India.

  • Killol Nathubhai Desai Assistant Professor in Pathology Department, GMERS Medical collage, Junagadh
  • Vidya Kantilal Satapara Tutor, Department of Anatomy, GMERS Medical College, Junagadh, Gujarat, India
Keywords: Angiogenesis, menstrual disorders, dysfunctional uterine bleeding, endometrium


Backgound: Menstrual disturbance is one of the commonest gynecological problems. Majority of these women have dysfunctional uterine bleeding (DUB), the rest being associated with leiomyomas, carcinomas, adenomyosis, endometrial polyps, hyperplasia and oral contraceptive uses.Aims:  To study of alteration in blood vessels morphology in various menstrual disorders have significant role in prognosis and in various anti-angiogenic therapies.Methods : A Cross-sectional study done at Anand, Surendranagar and Junagadh district from October 2011 to October 2016. 1867 endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. 761 cases were taken as control and 1106 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility, atrophic endometrium, endometrial hyperplasia, pill endometrium and carcinomas. Using light microscopy, the vascular morphology was studied. Statistical analyses were performed using the IBM SPSS (Statistical package for the Social Sciences v15.0) and Microsoft Excel 2007 software.Results: The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB.Conclusions: The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies. DOI: 10.21276/APALM.1180

Author Biographies

Killol Nathubhai Desai, Assistant Professor in Pathology Department, GMERS Medical collage, Junagadh
Assistant Professor in Pathology Department, GMERS Medical collage, Junagadh
Vidya Kantilal Satapara, Tutor, Department of Anatomy, GMERS Medical College, Junagadh, Gujarat, India
Tutor, Department of Anatomy, GMERS Medical College, Junagadh, Gujarat, India


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Original Article