Clinicopathological study of Sinonasal Masses

  • Prashant Shivaji Mane Grant Government Medical College, Mumbai
  • Shubhangi Vinayak Agale Grant Government Medical College, Mumbai, Maharashtra
Keywords: nasal cavity, paranasal sinus, polyp, nasal obstruction.

Abstract

Background: Sinonasal mass is a common finding in the Otorhinolaryngology Department. These can be non-neoplastic or neoplastic. Nasal obstruction is the most common clinical presentation. Imaging studies are not always conclusive in these cases. So, the present study aimed at clinical presentation and histopathological classification of sinonasal masses.Methods: All the specimens received as sinonasal mass were included in the present study. The tissues were routinely processed for histopathological examination and were stained by Hematoxylin and Eosin stain. Special stains were used wherever required. Immunohistochemistry was carried on cases with diagnostic difficulties.Result: Non-neoplastic lesions outnumbered the neoplastic lesions. Among the neoplastic lesions, benign tumours were more common than malignant tumours. Non-neoplastic lesions and benign tumours were commonly seen middle age group while malignant tumours were seen in adult patients.  Males were predominantly affected in non-neoplastic lesions and benign tumours. Malignant tumours showed female dominance. Nasal obstruction was the most common complaint. Overall, inflammatory nasal polyps were most common lesions. Inverted papillomas were most common benign tumours. Sinonasal undifferentiated carcinomas accounted for majority of malignant tumours.Conclusion: Sino-nasal masses or polyps can be non-neoplastic or neoplastic lesions and histopathological examination remains the mainstay in differentiating these lesions. DOI: 10.21276/APALM.1207

References

1. Lingen MW. Head and neck. Chapter 16; In Kumar V, Abbas A K, Fausto N, Aster J C, eds. Robbins and Cotran Pathologic basis of disease, 8th ed. Elsevier: Haryana, India; 2010:751-2.
2. Modh SK, Delwadia KN, Gonsai RN. Histopathological spectrum of sinonasal masses- A study of 162 cases. Int J Cur Res Rev 2013; 5(3): 83-91.
3. Hedman J, Kaprio J, Poussa T, Nieminen MM. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol. 1999 Aug; 28(4): 717-22.
4. Barnes L, Tse LL, Hunt JL, Gensler BM, Curtin HD, Boffetta P. Tumours of the nasal cavity and paranasal sinuses. In: Leon B, John WE, Peter R, David S, editors. IARC WHO classification of tumours, pathology and genetics of head and neck tumours. Lyon: IARC Press:2005.9‑82.
5. Humayun AHM, ZahurulHuq AHM, Ahmed SMT et al. Clinicopathological study of sinonasal masses. Bangladesh J Otorhinolaryngol 2010;16:15–22.
6. Gupta N, Kaur J, Srinivasan R, Das A, Mohindra S, Rajwanshi A, et al. Fine needle aspiration cytology in lesions of the nose, nasal cavity and paranasal sinuses. ActaCytol 2011;55:135‑41.
7. Nigam JS, Misra V, Dhingra V, Jain S, Varma K, Singh A. Comparative study of intra-operative cytology, frozen sections, and histology of tumor and tumor-like lesions of nose and paranasal sinuses. J Cytol 2013;30:13-7.
8. Khan N, Zafar U, Afroz N, Ahmad SS, Hasan S. Masses of nasal cavity, paranasal sinuses and nasopharynx: a clinicopathological study. Indian Journal of Otolaryngology and Head and Neck Surgery 2006;58(3):259-63.
9. Parajuli S, Tuladhar A. Histomorphological spectrum of masses of the nasal cavity, paranasal sinuses and nasopharynx. J Pathol Nepal 2013;3:351–5.
10. Kulkarni AM, Mudholkar VG, Acharya AS, Ramteke RV. Histopathological Study of Lesions of Nose and Paranasal Sinuses. Indian J Otolaryngol Head Neck Surg 2012;64(3):275–279.
11. Jyothi A Raj, Sharmila PS, Mitika Shrivastava, Mahantachar V, T Rajaram. “Morphological spectrum of lesions in the sinonasal region”. Journal of Evolution of Medical and Dental Sciences 2013;2,(37)7175-7186.
12. Lathi A, Syed MMA, Kalakoti P, Qutub D, Kishve SP. Clinicopathological profile of sinonasal masses: a study from a tertiary care hospital of India. Acta Otorhinolaryngol Ital 2011;31(6):372–7.
13. Venkatarajamma K, Joshyam S, Gowda B, Zebanoorain. Clinic-Pathological Profile of Sinonasal Masses. Int J Gen Med Pharm 2015;4(2):7–18.
14. Tikaram A, Prepageran N. Asian nasal polyps: a separate entity? Med J Malaysia 2013;68(6):445–7.
15. Davidsson A, Hellquist HB. The So-Called “Allergic” Nasal Polyp. ORL J Relat Spec 1993;55:30-5.
16. Joshi SR, Nagare M. Case report Fungal Rhinosinusitis ( Aspergillosis ) -3 cases. 2015;4(2):314–7.
17. Navya BN. Role of Histopathology in the Diagnosis of Paranasal Fungal Sinusitis. J Dent Med Sci 2015;14(1):97–101.
18. Montone KT, Livolsi V a., Feldman MD, Palmer J, Chiu AG, Lanza DC, et al. Fungal Rhinosinusitis: A Retrospective Microbiologic and Pathologic Review of 400 Patients at a Single University Medical Center. Int J Otolaryngol 2012;12:1–9.
19. Soontrapa P, Larbcharoensub N, Luxameechanporn T. Fungal rhinosinusitis : a retrospective analysis of clinicopathologic features and treatment outcomes at ramathibodi hospital. Southeast Asian J Trop Med Public Health 2010;41(2):442-9.
20. Fazal-I-Wahid, Adil Khan, Iftikhar Ahmad Khan. Clinicopathological profile of fungal rhinosinusitis. Bangladesh J Otorhinolaryngol 2012;18(1):48-54.
21. Nayak M, Roul B, Agrawal K, Nayak S. Clinicopathological study of lesions of sinonasal tract & Distribution of Sinonasal tract lesions in difefferent age groups & Sex. International Journal of Advanced Research 2015;3(4):726-733.
22. Jaison J, Tekwani DT. Histopathological lesions of nasal cavity, paranasal sinuses and nasopharynx. Annals of Applied Bio-Sciences 2015;2(2):40-6.
23. Bijjaragi S, Kulkarni VG, Singh J. Histomorphological study of polypoidal lesions of nose and paranasal sinuses. Indian Journal of Basic and Applied Medical Research 2015;4(3):435-9.
24. Mohammed AW, Bakshi J, Nada R. Sinonasal undifferentiated carcinoma with contralateral cavernous sinus involvement – A rare presentation. Curr Res Microbiol Biotechnol 2013;1(2):58–61.
25. Kalpana Kumari MK, Mahadeva KC. Polypoidal lesions in the nasal cavity. J Clin Diagn Res. 2013 Jun;7(6):1040-42.
26. Santos MRM, Servato JPS, Cardoso SV, Faria PR De, Eisenberg LA, Dias FL, et al. Squamous cell carcinoma at maxillary sinus : clinicopathologic data in a single Brazilian institution with review of literature. Int J Clin Exp Pathol 2014;7(12):8823–32.
Published
2017-06-04
Issue
Vol 4 No 3 (2017)
Section
Original Article

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access at http://opcit.eprints.org/oacitation-biblio.html).