A Prospective & Multicentric Study of RBC Parameters in Patients of Sickle Cell Disorder
Keywords:
Sickle cell Disorder, RBC Parameters, Hb electrophoresis, Sickling test
Abstract
Background: Sickle cell disease (SCD) is an inherited blood disorder caused by abnormal haemoglobin. Present study was done to study the relationship of clinical presentation & haematological findings in case of symptomatic & asymptomatic sickle cell disorder patients.Methods: In the present study, the RBC parameters like Hb, MCV, MCH, MCHC, RDW, RBC COUNT & PCV were recorded & results of sickling test & Hb electrophoresis were used to confirm a case of sickle cell disorder.Result: Categorical Variables (age &sex ) were expressed in actual number & percentages. Continuous variables ( Hb, MCV, MCH, MCHC, RDW, RBC COUNT & PCV ) were presented as Mean. Continuous variables were compared between Sickle cell disease subjects, sickle cell trait subjects & normal subjects by one way Analysis of Variance (ANOVA) test.p value < 0.05 was considered to be statistically significantConclusion: The most number of symptomatic patients of sickle cell disorder were found in the 2nd decade of age, followed by 3rd decade. There was a greater percentage of female subjects detected as sickle cell Disease (52.7%) & Sickle cell trait (62.8%) which points towards female preponderance of sickle cell disorder. Weakness & fatigue were the predominant symptoms of presentations among both sickle cell disease & sickle cell trait subjects. The peripheral smear examination in sickle cell disorder predominantly shows normocytic to microcytic with hypochromic picture. DOI: 10.21276/APALM.1247References
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9. Akinbami A, Dosunmu A, Adediran A, Oshinaike O, Adebola P. Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria. BMC Res Notes. 2012 1;5:396. doi: 10.1186/1756-0500-5-396
2. Balgir RS, Sharma SK. Distribution of sickle cell hemoglobin in India. Indian J Hemat. 1988; 6:1-14.
3. Mohanty D, Mukherjee MB. Sickle cell disease in India. CurrOpinHematol. 2002; 9:117.
4. Kohchale SR, Raja IA. Hematological Profile of Sickle Cell Anemic Subjects from Gadchiroli District, Maharashtra, International J. of Life Sciences, 2015; Special Issue, A3,:153-156.
5. Kar BC, Devi S. Clinical profile of sickle cell disease in Orissa. Indian J Pediatr. 1997; 64:73-7.
6. Rao SS, Goyal JP, Raghunath SV, Shah VB. Hematological profile of sickle cell disease from South Gujrat, India. Hematol Rep. 2012;4(2):e8.
7. Ifeanyi1 OE, Nwakaego OB, Angela IO, Nwakaego CC. Haematological parameters among sickle cell anemia in steady state & haemoglobin AA individuals at Micheal Okpara, University of agriculture, Umudike, Abia state, Nigeria. Int.J.Curr. Microbiol. App. Sci , 2014; 3:1000-1005
8. Sameer MA, Kate R, Dagar V, et al. Diagnosis & haematological parameters of various haemoglobinopathies in paediatric age group by using Cation exchange HPLC : A hospital based cross sectional study, IOSR Journal of Dental and Medical Sciences 2016;15:81-86.
9. Akinbami A, Dosunmu A, Adediran A, Oshinaike O, Adebola P. Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria. BMC Res Notes. 2012 1;5:396. doi: 10.1186/1756-0500-5-396
Published
2017-09-01
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