A Prospective & Multicentric Study of RBC Parameters in Patients of Sickle Cell Disorder

  • Prateek Pradeep Umrikar government medical college, bhavnagar, gujarat
  • Alpesh Prahladpuri Goswami
Keywords: Sickle cell Disorder, RBC Parameters, Hb electrophoresis, Sickling test


Background: Sickle cell disease (SCD) is an inherited blood disorder caused by abnormal haemoglobin. Present study was done to study the relationship of clinical presentation & haematological findings in case of symptomatic & asymptomatic sickle cell disorder patients.Methods: In the present study, the RBC parameters like Hb, MCV, MCH, MCHC, RDW, RBC COUNT & PCV were recorded & results of sickling test & Hb electrophoresis were used  to confirm a case of sickle cell disorder.Result: Categorical Variables (age &sex ) were expressed in actual number & percentages. Continuous variables ( Hb, MCV, MCH, MCHC, RDW, RBC COUNT & PCV ) were presented as Mean. Continuous variables were compared between Sickle cell disease subjects, sickle cell trait subjects & normal subjects by one way Analysis of Variance (ANOVA) test.p value < 0.05 was considered to be statistically significantConclusion: The most number of symptomatic patients of sickle cell disorder were found in the 2nd decade of age, followed by 3rd decade. There was a greater percentage of female subjects detected as sickle cell Disease (52.7%) & Sickle cell trait (62.8%) which points towards female preponderance of sickle cell disorder. Weakness & fatigue were the predominant symptoms of presentations among both sickle cell disease & sickle cell trait subjects. The peripheral smear examination in sickle cell disorder predominantly shows normocytic to microcytic with hypochromic picture. DOI: 10.21276/APALM.1247

Author Biography

Prateek Pradeep Umrikar, government medical college, bhavnagar, gujarat
3rd year resident, department of pathology


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Original Article