Inflammatory Myofibroblastic Tumour of Ovary Simulating Malignancy with Review of Literature

  • Ruchi Sinha ASSOCIATE PROFESSOR,DEPARTMENT OF PATHOLOGY ,ALL INDIA INSTITUTE OF MEDICAL SCIENCES-PATNA
  • Shuchi Smita SENIOR RESIDENT,DEPARTMENT OF PATHOLOGY,ALL INDIA INSTITUTE OF MEDICAL SCIENCES-PATNA
  • Iffat Jamal TUTOR,DEPARTMENT OF PATHOLOGY,ALL INDIA INSTITUTE OF MEDICAL SCIENCES-PATNA
  • Shashikant Kumar SENIOR RESIDENT,DEPARTMENT OF PATHOLOGY,ALL INDIA INSTITUTE OF MEDICAL SCIENCES-PATNA
  • Nishi Sharma TUTOR,DEPARTMENT OF PATHOLOGY,ALL INDIA INSTITUTE OF MEDICAL SCIENCES-PATNA
  • Mamta Kumari TUTOR,DEPARTMENT OF PATHOLOGY,ALL INDIA INSTITUTE OF MEDICAL SCIENCES-PATNA
Keywords: Inflammatory, myofibroblastic, tumour, malignancy, salpingo-oopherecromy

Abstract

Inflammatory myofibroblastic tumour (IMT) of ovary is an uncommon benign neoplasm that can mimic malignancy. It often occurs in children and young adults. Lung is the most common site of IMT.  Precise etiology is not known but recent reports suggested the role of benign reactive process in its pathogenesis.A 32 year old female patient presented to the gynaecology out patient department with complaints of lower abdominal pain and increased frequency of micturition with burning since 15 days. On per abdominal examination, an irregular lump of 18 weeks size with restricted mobility was palpable in suprapubic region. Laboratoratory investigations revealed normocytic normochromic anaemia with neutophilic leucocytosis and raised ESR. Her serum CA 125 levels were slightly raised (44.30 u/ml). Imaging studies showed an infiltrating mass in the pelvis. The patient underwent total abdominal hysterectomy with bilateral salpingo oopherectomy and omentectomy. Histopathological examination of which revealed IMT of right ovary with extension to right  parametrium and adjacent bladder.As IMT is a mimicker of malignancy due to its infiltrative growth. Histopathological examination is mandatory for its diagnosis and treatment. Misdiagnosis can lead to unnecessary extensive debulking surgeries and even chemotherapy. Rarity of this entity in the ovary has made this case worth reporting. DOI: 10.21276/APALM.1285 

References

Fletcher CDM, Bridge JA, Hogendoorn PCW et al. Inflammatory myofibroblastic tumour. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. Lyon International Agency for Research on Cancer. World Health Organization Classification of Tumours of Soft Tissue and Bone. 4th edition;2013: 83-4.

2. Olgan, S, Saatli, B et al. Hysteroscopic excision of inflammatory myofibroblastic tumor of the uterus: as case report and brief review. Eur. J. Obstet. Gynecol Reprod. Biol.2011;157: 234–240.
3. Shintaku, M, Fukushima A. Inflammatory myofibroblastic tumor of the uterus with prominent myxoid change. Pathol. Int.2006; 56 :625–628.
4. Bharatnur S, Ramkumar V, K Natrajan. Inflammatory Pseudo-Tumor Of Ovary - A Case Report. The Internet Journal of Gynecology and Obstetric.2012;16:1.
5. Sahnoun L, Elezzi O, Maazoun K, Krichene I et al. Ovarian inflammatory myofibroblastic tumor in children. J Pediatr Adolesc Gynecol. 2007 ;20(6):365-6.
6. Wang TY, Chou JW, Shih YS et al. Inflammatory myofibroblastic tumor mimicking adrenal incidentaloma. Intern Med. 2011;50: 165–6.
7. Coffin CM, Humphrey PA, Dehner LP . Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Semin Diagn Pathol .1998;15: 85-101.
8. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol.1995; 19: 859-872.
9. Gomez-Roman JJ, Vinyals GO,Velasco PS et al. Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor). Lab Invest.2006; 80:1121-1126.
10. Vujanic GM, Milovanovic D, Aleksandrovic S. Aggressive inflammatory pseudotumor of the abdomen 9 years after therapy for Wilms tumor. A complication, coincidence, or association? Cancer.1992; 70: 2362-2366.
11. Poh CF, Priddy RW, Dahlman DM. Intramandibular inflammatory myofibroblastic tumour: A true neoplasm or reactive lesion? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:460–6.
12. Volker HU, Scheich M, Holler S et al. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumour: Report of two cases with similar morphology. Diagn Pathol. 2007;2:1–7.
Published
2017-08-25
Issue
Vol 4 No 4 (2017)
Section
Case Report

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