Study on Mean Platelet Volume And Platelet Count In Diabetes Mellitus Type 2
Keywords:
Diabetes mellitus, Fasting blood sugar, Mean Platelet Volume, Platelet count
Abstract
Background: Most Diabetes Mellitus related deaths are due to increased risk of micro- and macrovascular complications of the disease. Larger platelets with higher mean platelet volume increase the propensity to thrombosis. Therefore, increased MPV is emerging as a risk factor for vascular complications.Methods: This prospective study was conducted on 100 subjects with type II DM and 50 non-diabetic controls over a period of 3 months. To determine mean platelet volume (MPV) and platelet count (PC) in diabetics (type2) and non-diabetics and to determine correlation of MPV and platelet count with fasting blood sugar.Results: Significant increase in value of MPV was seen in diabetics.Conclusion: MPV being a simple, economical test, can serve as an effective tool in monitoring the patients for thrombogenicity especially in patients with altered blood glucose metabolism. DOI: 10.21276/APALM.1381References
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8.Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK and Lakshmaiah V. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians 2012; 4: 5-9.
9.Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis. Int J Clin Exp Med. 2014;7(4):955–61.
10.Ozder A, Eker HH. Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care. Int J Clin Exp Med.2014;7:2292–2297.
11.Coban E, Kucuktag S, Basyigit S. Platelet activation in subjects with impaired glucose tolerance. Platelets. 2007;18(8):591-594.
12.Dayal A, Kothari S, Shah RJ, Patel SM. Mean Platelet Volume In Diabetes Mellitus Type 2. APALM. 2016 Dec 15;3(6):A567-572
13.Shah B, Sha D, Xie D, Mohler ER 3rd and Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: The national health and nutrition examination surveys, 1999-2004. Diabetes Care 2012; 35:1074-1078.
14.Kim JH, Kang JI, Kim JW, Kim SY and Bae HY. The relationship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean population: Gender differences. Platelets 2013; 24:469-473.
15.Hekimsoy Z, Payzinb B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications. 2004;18(3):173–176.
2. Yenigün E. Increased mean platelet volume in type 2 diabetes mellitus. Dicle Medical Journal/Dicle Tıp Dergisi. 2014;41(1):17-22.
3.Mahsud MAJ, Khan A, Hussain J. Hematological Changes in Tobacco using Type 2 Diabetic Patients.Gomal J Med Sci 2010;8:8-11.
4.King H, Aubert Re, Herman WH. Global burden of diabetes,1995-2025: prevelance, numerical estimates, and projections. Diabetes Care 1998;21:1414-31.
5.Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-384.
6. Coppinger JA, Cagney G, Toomey S, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 2004;103:2096-2104.
7.Akinsegun A, Akinola Olusola D, Sarah JO, et al. Mean platelet volume and platelet counts in type 2 diabetes: mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria. Pan Afr Med J.2014;18:42.
8.Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK and Lakshmaiah V. Mean platelet volume in Type 2 diabetes mellitus. J Lab Physicians 2012; 4: 5-9.
9.Ulutas KT, Dokuyucu R, Sefil F, Yengil E, Sumbul AT, Rizaoglu H, et al. Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis. Int J Clin Exp Med. 2014;7(4):955–61.
10.Ozder A, Eker HH. Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care. Int J Clin Exp Med.2014;7:2292–2297.
11.Coban E, Kucuktag S, Basyigit S. Platelet activation in subjects with impaired glucose tolerance. Platelets. 2007;18(8):591-594.
12.Dayal A, Kothari S, Shah RJ, Patel SM. Mean Platelet Volume In Diabetes Mellitus Type 2. APALM. 2016 Dec 15;3(6):A567-572
13.Shah B, Sha D, Xie D, Mohler ER 3rd and Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: The national health and nutrition examination surveys, 1999-2004. Diabetes Care 2012; 35:1074-1078.
14.Kim JH, Kang JI, Kim JW, Kim SY and Bae HY. The relationship between mean platelet volume and fasting plasma glucose differs with glucose tolerance status in a Korean population: Gender differences. Platelets 2013; 24:469-473.
15.Hekimsoy Z, Payzinb B, Ornek T, Kandogan G. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications. 2004;18(3):173–176.
Published
2017-10-25
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