Significance Of Micro Vessel Density In Invasive Breast Carcinoma

  • Divya rani M.N Department of pathology Bangalore Medical College KR Market, Karnataka India
  • Harendra Kumar M.L Department of pathology Sri Devraj Urs medical College Tamaka, Kolar,Karnataka India 563101
  • Swaroop Raj B.V Department of pathology Sri Devraj Urs medical College Tamaka, Kolar,Karnataka India 563101
Keywords: Breast cancer, Micro vessel density, CD 34, Immunohistochemistry.


Introduction: Breast cancer remains a leading cause of death in women of reproductive age group.  Angiogenesis in breast carcinoma has been extensively studied and proven to play an important role is tumour outcome and patient prognosis. The prognostic relevance of angiogenesis expressed as microvessel density has been reported in various neoplasms.Aim: Our aim was to study the correlation of microvessel density in breast carcinomas.Materials and methods: Microvessel density quantification was done using immunohistochemistry technique with CD34 monoclonal antibody in a series of 55 cases of breast carcinoma. Microvessels were counted within a 200 X magnification field in the area of highest microvessel density and the results were correlated with tumour grade.Result: Microvessel density was highest in grade III breast tumours (132 ±18.7).Conclusion: In the present study, intra tumoral mean MVD was highest in grade III tumors suggesting that tumour angiogenesis correlates with tumour grade. However larger sample size would be required to decide cut-off values between different grades.DOI:10.21276/APALM.1436


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Original Article