Role of Mean platelet Volume as an adjunct in evaluation of acute inflammation.

  • Nabila Afsar Deccan College of Medical Sciences
  • Idrees Akhtar Afroze Deccan College of Medical Sciences
  • Habeebunnisa Tahniath Deccan College of Medical Sciences
  • Zakia Abid Deccan College of Medical sciences
Keywords: MPV, mean platelet volume, inflammation, neutrophilic leucocytosis, platelet activation


Background: Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker.Methods:  A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed.Results: MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis.Conclusion:  MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis. DOI: 10.21276/APALM.1486 

Author Biographies

Nabila Afsar, Deccan College of Medical Sciences
Assistant Professor,Department of pathology
Idrees Akhtar Afroze, Deccan College of Medical Sciences
ProfessorDepartment of Patholgy
Habeebunnisa Tahniath, Deccan College of Medical Sciences
Post graduateDepartment of pathology
Zakia Abid, Deccan College of Medical sciences
Professor and Head of departmentDepartment of Pathology


1. Projahn D, Koenen RR. Platelets. Key players in vascular inflammation. J Leukoc Biol. 2012;92(6):1167-1175.
2. Larsen SB, Grove EL, Hvas AM, Kristensen SD. Platelet turnover in stable coronary artery disease-influence of thrombopoietin and low-grade inflammation. PLoS One 2014;9:e85566. 3. Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R, et al. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997;17:802–7.
4. Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clin Chem 1997;43:1072–76.
5. Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochemia Medica. 2016;26(2):178-193.
6.Smyth SS, McEver RP, Weyrich AS et al. 2009 Platelet Colloquium Participants: Platelet functions beyond hemostasis. J Thromb Haemost. 2009; 7(11)
7. Gao Y, Li Y, Yu X et al. The impact of various platelet indices as prognostic markers of septic shock. PLoS One. 2014; 9(8)
8.Ozturk N, Baygutalp NK, Bakan E, Altas GF, Polat H, Dorman E. Changes in platelet parameters in leukocytosis. The Pan African Medical Journal. 2016;24:185.
9. Gurler, Mujgan; AKTAS, Gulali. A review of the association of mean platelet volume and red cell distribution width in inflammation. Int J Res Med Sci, 2016 4(1) 1-4.
10. Özturk ZA, Dag MS, Kuyumcu ME, et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci; 2013;17:334-341
11. Fan Z, Pan J, Zhang Y, et al., “Mean Platelet Volume and Platelet Distribution Width as Markers in the Diagnosis of Acute Gangrenous Appendicitis,” Disease Markers, 2015,(2015),1-4.
12. Koç S, Eyibilen A, Erdoğan AS. Mean Platelet Volume as an Inflammatory Marker in Chronic Sinusitis, Eur J Gen Med 2011;8(4):314-317
13. Bozkurt S, Köse A, Erdogan, et al. MPV and other inflammatory markers in diagnosing acute appendicitis. JPakMedAssoc; 2015;65(6): 637-641
14. Zareifar S., Farahmand Far MR, Golfeshan F, Cohan, N. Changes in Platelet Count and Mean Platelet Volume During Infectious and Inflammatory Disease and Their Correlation With ESR and CRP. J. Clin. Lab. Anal., 2014;28: 245–248.
15. Van der Lelie J, Von dem Borne AK. Increased mean platelet volume in septicaemia. J Clin Pathol 1983;36: 693–696
16. McMillan R. Therapy for adults with refractory chronic immune thrombocytopenic purpura.Ann Intern Med 1997;126:307-314.
17. Kaushansky K , Gerald J Roth. Megakaryocytes and platelets. In: John P Greer, John Foerster, John N Lukens, George M Rodgers, Frixos Paraskevas, Bertil Glader, editors. Wintrobe’s clinical Hematology. 11th edition. Philadelphia. Lippincott Williams & Wilkins; 2004: 632
18. Van der Lelie J, Von dem Borne AK. Platelet volume analysis for differential diagnosis of thrombocytosis. Journal of Clinical Pathology. 1986;39(2):129-133.
19. Robbins G, Barnard DL. Thrombocytosis and microthrombocytosis: a clinical evaluation of 372 cases. Acta Haematol 1983;70:175-82.
20. de Stoppelaar SF , van ‘t Veer C, van der Poll T. The role of platelets in sepsis. Thrombosis and Haemostasis 2014; 112: 627-842.
Original Article