Expression of PSMA in Thyroid follicular neoplasms: Utility for differentiating between benign from malignant lesions

  • Hiva Saffar Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Marzieh kiany Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Mohammad Tavangar Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Elham Mirzaian Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Keywords: Angiogenesis, Prostate-Specific Membrane Antigen, Thyroid Follicular Adenoma, Thyroid Follicular Carcinoma

Abstract

Back ground: Prostate-Specific membrane Antigen has been known as a tumor associated neovasculature marker in some solid malignant tumors and targeting of that by cytotoxic- conjugated antibody can represent powerful tool for vascular targeted therapy in malignant tumors. In thyroid, it appears that angiogenesis factors are involved in neoplastic growth and aggressiveness of tumors.This study was conducted to evaluate the expression of PSMA as an angiogensis factor by immunohistochemistry in neovasculature of thyroid follicular neoplasms to determine its usefulness for distinguishing between adenoma and carcinoma .Methods: Paraffin Blocks of formalin fixed samples representing 48 cases of Follicular Thyroid adenoma and 15 cases of Follicular Thyroid Carcinoma were evaluated.Results: Among Carcinomas, capsular and vascular invasion were present in 12 and 11 cases , respectively.The intensity of PSMA staining was significantly higher in carcinoma group(p=0.028). However, no significant difference in extent of PSMA expression in adenoma and carcinoma groups was observed(p=0.239).Thyroid follicular cells in adenoma, carcinoma also non neoplastic area  were negative for PSMA. Conclusion: Our findings do not support usefulness of PSMA in differentiating between FTA and FTC. However ; expression in neovasculature  of differentiated thyroid tumors can represent a potential utility for PSMA-targeted radionuclide therapy in advanced differentiated thyroid cancers.DOI:10.21276/APALM.1511

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Published
2017-10-27
Issue
Vol 4 No 5 (2017)
Section
Original Article

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