Fine needle Aspiration Cytology: Diagnostic Efficacy in Malignant Breast Lesions
Keywords:
Breast lump, Fine needle aspiration, Malignancy, Invasive carcinoma
Abstract
Background: A palpable breast lump is a common problem encountered by both the general practitioner and the surgeon. FNAC is a rapid, simple, efficient and safe method for diagnosis of palpable breast lumps. It is very useful as a pre-operative diagnostic tool.The study was carried out to diagnose palpable lumps by cytology and to confirm them with histopathologic study wherever possible. Taking histopathology as the gold standard, the sensitivity, specificity and diagnostic accuracy of FNAC in all cases diagnosed as malignant by cytology were obtained. Methods: FNAC was performed in all patients who presented with a palpable breast lump & the cytological findings were recorded. Subsequent histopathologic study was done wherever possible on all cases reported as malignant or suspicious for malignancy on cytology. Result: A correlation of 97.67% was obtained in malignant lesions of the breast. Sensitivity was 100%; specificity and diagnostic accuracy were 97.67% each. Conclusion: FNAC as a diagnostic modality for palpable breast lumps is a very efficient, rapid, safe and inexpensive method. In spite of its limitations, FNAC offers a high rate of sensitivity and specificity which makes it a valuable tool for the preliminary diagnosis and management of breast lumps.DOI: 10.21276/APALM.1662References
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9. Mulazim HB, Madiha A, Shahid J, Shahida N, Bashir S, Irfan M. Bakhshi,nd Shaharyar. Use of Fine-Needle Aspiration in the Evaluation of Breast Lumps. Pathology Research International Volume 2011, Article ID 68952.
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12. Ozkara SK, Ustun MO, Paksoy N. The gray zone in breast fine needle aspiration cytology. How to report on it? Acta Cytol 2002 May-Jun. 46(3):513-8.
13. Mitra S, Dey P. Grey zone lesions of breast: Potential areas of error in cytology. Journal of Cytology / Indian Academy of Cytologists 2015. 32(3):145-152.
14. Young, Nancy A, et al. Diagnosis and subclassification of breast carcinoma by fine-needle aspiration biopsy: results of interlaboratory comparison program in non-gynaecologic cytopathology. Arch Pathol Lab Med 2002; 126: 1453-1457.
15. Jan F. Silverman. Breast. In: Marluce Bibbo. Comprehensive Cytopathology. 4th ed. Philadelphia: W. B. Saunders company, 2014.
16. Gomez-Aracil V, Mayayo E, Azua J, Arraiza A. Papillary neoplasms of the breast: clues in fine needle aspiration cytology. Cytopathology 2002, 13: 22–30
17. Prathiba D, Rao S, Kshitija K, Joseph LD. Papillary lesions of breast – An introspect of cytomorphological features. J Cytol. 2010, 27(1):12-5.
18. Tse GM, Ma TK, Lui PC, Ng DC, Yu AM, Vong JS, Niu Y, Chaiwun B, Lam WW, Tan PH. Fine needle aspiration cytology of papillary lesions of the breast: how accurate is the diagnosis? J Clin Pathol. 2008 Aug; 61(8):945-9.
19. Rajesh L, Dey P, Joshi K. Fine needle aspiration cytology of lobular breast carcinoma. Comparison with other breast lesions. Acta Cytol 2003, 47(2):177-82.
20. Cytologic Diagnosis of Lobular Carcinoma of the Breast Experience With 555 Patients in the Rene Huguenin Cancer Center. Emmanuelle Menet, Eronique Becette V, Marianne Briffod, Cancer Cytopathology 2008, Vol.14, Issue 2
2. Nagrani RT, Budukh A, Koyande S, Panse NS, Mhatre SS, Badwe R. Rural urban differences in breast cancer in India. Indian J Cancer 2014;51:277 81
3. Mulazim HB, Madiha A, Shahid J, et al. Use of Fine-Needle Aspiration in the Evaluation of Breast Lumps. Pathology Research International, vol. 2011, Article ID 689521.
4. Kharkwal S, Sameer , Mukherjee A. Triple test in carcinoma breast. J Clin Diagn Res. 2014; 8(10):NC09–11.
5. Yu Y-H, Wei W, Liu J-L. Diagnostic value of fine-needle aspiration biopsy for breast mass: a systematic review and meta-analysis. BMC Cancer 2012;12:41.
6. Kanchanabat B, Kanchanapitak P, Thanapongsathorn W, Manomaiphiboon A. Fine-needle aspiration cytology for diagnosis and management of palpable breast mass. Aust NZ J Surg. 2000;70:791–794.
7. Kaur G, Sivakumar S . Comparison of unsatisfactory aspirates in fine needle aspiration performed by surgical medical officers and pathologists. Journal of Cytology, Vol. 24, No. 2, April-June, 2007, pp. 82-84
8. Svante R Orell, Gregory F Sterrett, Darrel Whitaker, Philippe Vielh. Techniques of FNA Cytology. In Svante R Orell, Gregory F Sterrett, Darrel Whitaker. Fine Needle Aspiration Cytology. 5th ed. New Delhi: Elsevier India Pvt. Ltd, 2011, Page No. 8-27.
9. Mulazim HB, Madiha A, Shahid J, Shahida N, Bashir S, Irfan M. Bakhshi,nd Shaharyar. Use of Fine-Needle Aspiration in the Evaluation of Breast Lumps. Pathology Research International Volume 2011, Article ID 68952.
10. Paulo M, Maribel L, Puay-Hoon Tan, and Gary M. Tse. Fine Needle Aspiration Cytology of the Breast: The Nonmalignant Categories, Pathology Research International, vol. 2011, Article ID 547580.
11. Phuong Viet The Tran, Philip C. W. Lui, Alex M. C. Yu, Pham The Vinh, Helen H. L. Chau, Tony K. F. Ma, Puay-Hoon Tan, Gary M. Tse. Atypia in fine needle aspirates of breast lesions. J Clin Pathol 2010. 63:585-591.
12. Ozkara SK, Ustun MO, Paksoy N. The gray zone in breast fine needle aspiration cytology. How to report on it? Acta Cytol 2002 May-Jun. 46(3):513-8.
13. Mitra S, Dey P. Grey zone lesions of breast: Potential areas of error in cytology. Journal of Cytology / Indian Academy of Cytologists 2015. 32(3):145-152.
14. Young, Nancy A, et al. Diagnosis and subclassification of breast carcinoma by fine-needle aspiration biopsy: results of interlaboratory comparison program in non-gynaecologic cytopathology. Arch Pathol Lab Med 2002; 126: 1453-1457.
15. Jan F. Silverman. Breast. In: Marluce Bibbo. Comprehensive Cytopathology. 4th ed. Philadelphia: W. B. Saunders company, 2014.
16. Gomez-Aracil V, Mayayo E, Azua J, Arraiza A. Papillary neoplasms of the breast: clues in fine needle aspiration cytology. Cytopathology 2002, 13: 22–30
17. Prathiba D, Rao S, Kshitija K, Joseph LD. Papillary lesions of breast – An introspect of cytomorphological features. J Cytol. 2010, 27(1):12-5.
18. Tse GM, Ma TK, Lui PC, Ng DC, Yu AM, Vong JS, Niu Y, Chaiwun B, Lam WW, Tan PH. Fine needle aspiration cytology of papillary lesions of the breast: how accurate is the diagnosis? J Clin Pathol. 2008 Aug; 61(8):945-9.
19. Rajesh L, Dey P, Joshi K. Fine needle aspiration cytology of lobular breast carcinoma. Comparison with other breast lesions. Acta Cytol 2003, 47(2):177-82.
20. Cytologic Diagnosis of Lobular Carcinoma of the Breast Experience With 555 Patients in the Rene Huguenin Cancer Center. Emmanuelle Menet, Eronique Becette V, Marianne Briffod, Cancer Cytopathology 2008, Vol.14, Issue 2
Published
2018-01-28
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