Leiomyomatous hamartoma of the pyloric antrum: A Case Report
Keywords:
Gastric antrum, Hamartoma, Leiomyoma
Abstract
Leiomyomatous hamartomas are extremely rare lesions with very few cases being reported in the lungs and the oral cavity. There has been no published report of gastric leiomyomatous hamartoma till date. We present a case of leiomyomyomatous hamartoma in the pyloric antrum clinically mimicking a gastrointestinal stromal tumour. A 49-year old female presented with abdominal pain since 3 months. Endoscopy and Contrast-enhanced CT showed a large, well-defined, submucosal lesion in the antropyloric region, causing mild luminal compromise. In our case, distal gastrectomy (Bilroth 1) was done. Histopathological examination revealed a lesion comprising of proliferating connective tissue with smooth muscle fascicles dispersed in loose fibrous stroma, nerves and multiple small vessels. Immunophenotyping with smooth-muscle actin and desmin supported the diagnosis. We report this rare case and suggest the inclusion of leiomyomatous hamartoma in the differential diagnosis of gastric lesions with smooth muscle as a dominant component.References
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2. Alberecht H. Hamartoma. Verh Dtsch Ges Pathol. 1904;7:153-57.
3. Nava-Villalba M, Ocampo-Acosta F, Seamanduras-Pacheco A, Aldape-Barrios BC. Leiomyomatous hamartoma: report of two cases and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:e39-e45.
4. Wolff M, Kaye G, Silva F. Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms. Report of nine cases, including three males. Am J Surg Pathol. 1979;3:325-42.
5. Gal AA, Brooks JSJ, Pietra GG. Leiomyomatous neoplasms of the lung: a clinical, histologic, and immunohistochemical study. Mod. Pathol. 1989;2:209-216.
6. Itoh H, Yanagi M, Setoyama T, et.al. Solitary fibroleiomyomatous hamartoma of the lung in a patient without a pre-existing smooth muscle tumor. Pathology International. 2001; 51: 661-65.
7. Zaitoun H, Triantfyllou A. Smooth muscle hamartoma of the hard palate. J Oral Pathol Med. 2007;36:245-49.
Published
2015-11-01
Issue
Section
Case Report
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