Fungal Biofilm & Medical Device Associated Infection: It’s Formation, Diagnosis & Future Trends: A Review

  • Seema Bose Pravara Institute of Medical Sciences
  • Atindra Krishna Ghosh Pravara Institute of Medical Sciences
Keywords: Fungal biofilm, Biomedical device, Quorum sensing, IBIS T 5000, Electrochemical sensor,


Fungal biofilm has been associated with a wide range of persistent infections, which responds poorly to antifungal drugs. In modern day critical care; use of life saving medical devices encourages biofilm formation. Formation of biofilm on devices and prolonged hospital stay cause resistance of microorganisms to antifungal drugs. Development of resistance is due to genetic and biochemical changes in fungal cells and production of exopolysaccharide matrix. Fungal biofilm is a heterogeneous structure. There are three stages of biofilm formation, such as, microbial adhesion, maturation and disposal of biofilm. Besides, quorum-sensing play an important role in maturation and dispersion of biofilm cells. Biofilm can be detected by culture – based methods, microscopy and genotypic methods. In future, research on innovation of medical devices, newer and early diagnostic methods, new drug molecules, synthetic peptides, electrochemical sensors, atmospheric pressure and non – thermal plasma have scope to deal with biofilm – associated infection.

Author Biographies

Seema Bose, Pravara Institute of Medical Sciences
Professor, Microbiology department
Atindra Krishna Ghosh, Pravara Institute of Medical Sciences
Microbiology, Professor


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