Seroprevalence of Co-Infections Among Blood Donors in A Blood Bank of A Tertiary Health Care Centre
Keywords:
Co-infection, HIV, HBV HCV, Malaria, Syphilis, Transfusion.
Abstract
INTRODUCTION: Transfusion transmissible infections (TTIs) like HIV, HBV, HCV, syphilis and malaria are major problems associated with blood transfusion practices. Because of shared modes of transmission, co-infection with HIV, HBV and HCV is a significant occurrence, particularly in areas where these viruses are endemic and even amongst apparently healthy subjects like blood donors. Hence the study was undertaken to analyze the prevalence and patterns of co-infections among voluntary and replacement donors in our geographical areaMETHODS: The present study was carried out in Blood bank of S.N Medical College, Bagalkot from July 2012 to June 2013. Two ml of blood sample was collected in labeled pilot tube at the time of collection of blood from donor tubing of blood bag. Serum was separated. The samples were tested for HIV, HBV, HCV, Malaria and Syphilis.RESULTS: Out of the 8187 blood donors, 7461 (91.13%) were replacement donors and remaining 726 (8.87%) were voluntary donors. Co-infection was seen in 8 (0.09%) donors.CONCLUSION: Co infections are more common among replacement donors. Since co infected individuals are at greater risk of hepatotoxicity following treatment with antiviral drugs, care should be taken to detect all infections among otherwise healthy donors.References
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12. Chavan SK, Chavan KB. Seroprevalence, trend of transfusion transmittable infections and co-infections rate among blood donors at tertiary care hospital – 10 years study. Int J Res Health Sci 2014;2: 1014-20.
13. Kaur G, Basu S, Kaur R, Kaur P, Garg S. Patterns of infections among blood donors in a tertiary care centre: A retrospective study. Nat Med J India 2010; 23: 147-149.
14. Dogra M , Dogra A, Sidhu M, Kotwal U. Seroprevalence of coinfections among blood donors in tertiary health care centre of Jammu region. Ind J Med Microbiol.2015; 33: 181-182.
15. World Health Organisation (WHO). Blood safety strategy for the African Region. Brazzaville, World Health Organisation, Regional office for Africa (WHO/AFR/RC51/9 rev 1). 2002.
16. Kapur S, Mittal A. Incidence of HIV infection and its predictors in blood donors in Delhi. Indian J Med Res 1998;108:45–50.
17. Jain M, Chakravarti A, Verma V, Bhalla P. Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus. Indian J Pathol Microbiol 2009;52:17-9.
18. Dogra S, Gupta O, Singh M.S, Rawat S.S. Sero-prevalence of transfusion transmissible infections and co-infections among blood donors in a tertiary care hospital of the capital: three and half year study. Int J Recent trends in Sci and Technol.2014; 12: 105-109.
19. Mercy K.A, Ijeoma I, Emmanuel K.J, Nwanyibuaku N.G. Prevalence of Hepatitis B and human immunodeficiency virus co-infection among blood donors in Abia State University teaching hospital, Aba, South East, Nigeria. Int.J.Curr.Microbiol.App.Sci 2015; 4(3): 762-768.
20. Egah DZ, Banwat, EB, Audu ES, Iya DM, Mamdong BM, Awele AA and Gomwalk NE. Hepatitis B surface antigen, Hepatitis C and HIV antibodies in a low risk blood donor group, Nigeria. East Med Health J 2007; 13:211-215.
21. Oladele OO, Adesina TB, Omolola ZT, Sunday ST. Prevalence of HBsAg and HIV among blood donors in Osogbo, Osun State, Nigeria. Int Res J Med S 2013;1 (3): 66-71.
2. Zaraski JP, Bohn B, Bastie A, Pawlotsky JM, Baud M, Bost B. Characteristics of patients with dual infection by hepatitis B and C viruses. J Hepatol. 1998;28:27-33.
3. National Blood Policy 2007, National Aid Control Organization, Ministry of Health & Family Welfare, Government of India. Available from: www.naco.nic.in. Accessed 12-03-2013.
4. Country Scenario – an update; National Aids Control Programme India, December 1996.
5. Mathai J, Sulochana PV, Satyabhama S, Nair PK, Sivakumar S. Profile of transfusion transmissible infections an associated risk factors among blood donors of Kerala. Indian J Pathol Microbiol 2002; 45:319–22.
6. Nanu A, Sharma SP, Chatterjee K, Jyoti P. Markers for transfusion-transmissible infections in north Indian voluntary and replacement blood donors: Prevalence and trends 1989–1996. Vox Sang 1997; 73:70–3.
7. Alter MJ. Epidemiology of viral hepatitis and HIV co infection. J Hepatol 2006;44:S6-9.
8. Kaur P, Basu S. Transfusion transmitted infection: existing and emerging pathogens. J Postgrad Med 2005;51:146-51.
9. Kaur H, Sharma M, Mannan R, Manjari M, Chandey M, Madan M. Seroprevalence of HIV, Hepatitis B, Hepatitis C and Syphilis co infections among Donors in Tertiary Care Blood Bank, Punjab. Int J Den Med Res 2015; 5: 45-47.
10. Kochhar AK, Singh K, Kochhar SK. A Study To Assess Trend In Seroprevalence Of Hepatitis B Virus Infection Among Blood Donors Of Southern Haryana, India. The Internet Journal of Pathology [Internet] 2012;13(2): Available from: doi: 10.5580/2B93.
11. Singh B, Kataria SP, Gupta R. Infectious markers in blood donors of East Delhi: prevalence and trends. Indian J Pathol Microbiol. 2004; 47: 477-9.
12. Chavan SK, Chavan KB. Seroprevalence, trend of transfusion transmittable infections and co-infections rate among blood donors at tertiary care hospital – 10 years study. Int J Res Health Sci 2014;2: 1014-20.
13. Kaur G, Basu S, Kaur R, Kaur P, Garg S. Patterns of infections among blood donors in a tertiary care centre: A retrospective study. Nat Med J India 2010; 23: 147-149.
14. Dogra M , Dogra A, Sidhu M, Kotwal U. Seroprevalence of coinfections among blood donors in tertiary health care centre of Jammu region. Ind J Med Microbiol.2015; 33: 181-182.
15. World Health Organisation (WHO). Blood safety strategy for the African Region. Brazzaville, World Health Organisation, Regional office for Africa (WHO/AFR/RC51/9 rev 1). 2002.
16. Kapur S, Mittal A. Incidence of HIV infection and its predictors in blood donors in Delhi. Indian J Med Res 1998;108:45–50.
17. Jain M, Chakravarti A, Verma V, Bhalla P. Seroprevalence of hepatitis viruses in patients infected with the human immunodeficiency virus. Indian J Pathol Microbiol 2009;52:17-9.
18. Dogra S, Gupta O, Singh M.S, Rawat S.S. Sero-prevalence of transfusion transmissible infections and co-infections among blood donors in a tertiary care hospital of the capital: three and half year study. Int J Recent trends in Sci and Technol.2014; 12: 105-109.
19. Mercy K.A, Ijeoma I, Emmanuel K.J, Nwanyibuaku N.G. Prevalence of Hepatitis B and human immunodeficiency virus co-infection among blood donors in Abia State University teaching hospital, Aba, South East, Nigeria. Int.J.Curr.Microbiol.App.Sci 2015; 4(3): 762-768.
20. Egah DZ, Banwat, EB, Audu ES, Iya DM, Mamdong BM, Awele AA and Gomwalk NE. Hepatitis B surface antigen, Hepatitis C and HIV antibodies in a low risk blood donor group, Nigeria. East Med Health J 2007; 13:211-215.
21. Oladele OO, Adesina TB, Omolola ZT, Sunday ST. Prevalence of HBsAg and HIV among blood donors in Osogbo, Osun State, Nigeria. Int Res J Med S 2013;1 (3): 66-71.
Published
2016-02-29
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