Metaplastic carcinoma of the breast: a case report

  • T Santosh KIMS & RF
  • Epari Sanjeeva Rao Professor
  • B R Mohan Rao HOD, Professor
Keywords: Breast, Metaplastic Carcinoma, Diverse differentiation, Immunohistochemistry


Metaplastic Carcinomas of the breast are malignant neoplasms composed of both epithelial and mesenchymal elements. The rarity of this tumor is exemplified by the fact that it accounts for only about 0.2% of all breast carcinomas. It presents histologically with diverse differentiation and the exact histogenesis of this tumor is unknown. The present case is reported for its rarity.

Author Biographies

T Santosh, KIMS & RF
Asst Professor Department of Pathology.
Epari Sanjeeva Rao, Professor
Professor, KIMS ,Amlapuram
B R Mohan Rao, HOD, Professor
HOD, Professor, KIMS, Amlapuram


1. Ian OE, Andrew HSL, Sarah EP, Emad AR. Tu-mors of the Breast. In: Fletcher CDM, editor. Di-agnostic Histopathology of Tumors, 4nd ed. Vol.1, Elsevier Limited; 2000. p.1100-02.
2. Agarwal K, Kaur M, Bajaj P, Agarwal C, Patha-nia OP. Metaplastic Carcinoma of the breast. In-dian J Cancer. 2001; 38: 80-84.
3. Kiran A, Veena M, Husan H, Ghazal M. An un-usual case of metaplastic carcinoma (sarcomatoid variant). Indian J. Surg. 2003; 65:377-80.
4. Muhammad A, Humera M, Faheem M, Ahmed K, Javed I. Carcinosarcoma of the Breast. J. of the College of Physicians and Surgeons Pakistan 2012; 22:333-4.
5. Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas. II. Spindle cell carcinoma. Hum Pathol 1989; 20:732-40.
6. Atahan K, Gur S, Tarcan E, Vokmez A, Yigit S. Carcinosarcona of Breast. J Breast Health. 2007;3:85-86.
7. Carter MR, Harnick JL, Lester S, Fletcher CD. Spindle Cell (Sarcomatoid) carcinoma of breast a clinicopathological and immunohistochemical analysis of 29 cases. Am J. Surg. Pathology. 2006; 30:300-1.
8. Hennesy BT, Giordano S, Broglio K, Duan Z et al. Biphasic Metaplastic Sarcomatiod carcinoma of breast. Annals of Oncology. 2006; 17:605-13.
9. Adem C, Reynolds C, Adlakha H, Roche PC, Nascimento AG. Wide spectrum screening keratin as a marker of metaplastic spindle cell carcinoma of the breast: an immunohistochemical study of 24 patients. Histopathology. 2002; 40:556–62.
10. Tokudome N, Sakamoto G, Sakai G, Sakai T, Sarumaru S. A case of carcinosarcoma of the breast. Breast Cancer. 2005; 12:149-53.
Case Report