Correlation of Her-2/neu Status With Estrogen, Progesterone Receptors and Histologic Features in Breast Carcinoma

  • Anupama dayal
  • Rupal J Shah
  • Sadhana Kothari
  • S M Patel
Keywords: Breast carcinoma, Her-2/neu, ER/PR.


Background: Breast cancer is the commonest cancer in urban Indian females, and the second commonest cancer in the rural Indian women. One of the hallmark of the disease is expression of Estrogen Receptor (ER), Progesterone Receptor (PR) and Her-2/neu that ultimately drives prognosis & treatment modalities.Aims: This study is to evaluate the expression of ER and PR and Her-2/neu in Breast Carcinoma & to compare them with other prognostic parameters: histological type and grade, tumor size, patients' age and lymph node metastases.Method: 80 cases of Invasive Breast Carcinoma received as MRM (Modified Radical Mastectomy) over a period of 6-8 months were included. Routine H&E staining and IHC analysis for ER, PR and Her-2/neu was carried out in all cases.Result: Out of 80 cases, 69 (86%) cases were of Infiltrating Ductal Carcinoma with mean age of 53 years. ER, PR & Her-2/neu expression were seen in 56.9%, 35.5% & 21.3% respectively. ER, PR expressing tumours tend to be of lower grade I(p<0.05). 94.1% Her-2/neu expressing tumours presented with higher tumour grade (II, III) but statistically not significant. Lymph node metastases was found to be significantly associated with PR and Her-2/neu positive status (p=0.03, p=0.01 respectively).  Her-2/neu expression was inversely related to ER and PR expression (p<0.05).Conclusion: Higher number of grade 1 tumors showed ER, PR positivity as compared to grade 3 tumors. Inverse relationship was observed between Her-2/neu expression and ER, PR receptor status. Her-2/neu expression was associated with higher rate of axillary metastasis but did not show any significant correlation with age, tumour size and grade.


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Original Article