Analysis of distribution and patterns of ovarian lesions at a tertiary care hospital.
Keywords:
Ovarian lesions, distribution, benign, malignant.
Abstract
Background: Ovarian lesions manifest in a wide spectrum of clinical, morphological and histological features. The aim of this study was to analyze the distribution and patterns of these lesions at a tertiary care hospital.Methods: Retreivement and collection of the data was done along with demographic data including age, sex, Ultrasonography/Computed Tomography findings. The diagnosis was confirmed by histopathological examination. Correlation of histopathological patterns was done with age, bilaterality, type, size & morphology of the lesion.Results: Follicular cyst was the commonest non-neoplastic lesion of the ovary. Surface epithelial tumor was the commonest tumor according to the histogenesis followed by germ cell tumor. Among the malignant surface epithelial tumors, commonest type was serous cystadenocarcinoma followed by endometroid carcinoma. Serous cyst adenoma was the commonest tumor in benign category. In germ cell tumors category, benign mature teratomas constituted highest numbers (15 cases). Six cases of sex cord stromal tumor and 2 cases of metastatic tumors were also detected in the study.Conclusions: It is concluded from this study that benign ovarian tumors were more common than malignant ones across all age groups. Though a majority of the tumors were benign, more numbers of malignant tumours were observed in our study as compared to those by other authors, which is an alarming finding. As most of the malignant ovarian tumors present late, development of methods for early diagnosis & regular screening is a pressing need today.DOI:10.21276/APALM.1657References
1.Gupta N, Bisht D, Agarwal AK, Sharma VK. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Indian J Pathol Microbiogy. 2007; 50(3):525-27.
2. Juan Rosai. Female reproductive system-ovary: In: Michael Houston, Joanne Scott editor. Rosai & Ackermann’s Surgical Pathology. 10th ed. Missouri: Elsevier Inc; 2011: 2:1562.
3. Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A. Changing trends in incidence of ovarian cancer - the Indian scenario. Asian Pac J Cancer Prev .2009; 10:1025-30.
4. Indian Council of Medical Research. Three year report of Population based Cancer Registries: 2012-2014.Bangalore, India: NCDIR-NCRP; 2016.
5. Deligdisch L. Early Diagnosis of Ovarian Cancer. Is It Possible? Med J Obstet Gynecol. 2013; 1: 1003.
6. Lorena Dijmarescu and colab. Diagnosis Correlations in Ovarian Tumors. Current Health Sciences Journal. 2012; 38(1):31-34
7. Takano M, Kikuchi Y, Yaegashi N et al. Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer. 2006; 94: 1369–1374.
8. du Bois A, Lück HJ, Meier W et al. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst .2003; 95: 1320–1329.
9. Berek JS, Natarajan S. Ovarian and fallopian tube cancer. In: Berek JS editor. Berek & Novak’s gynecology.14th ed. New Delhi: Wolters Kluwer health (India) private limited; 2007: 1457-547.
10. Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST. CT and MR Imaging of Ovarian Tumors with Emphasis on Differential Diagnosis. Radiographics. 2002; 22:1305–25.
11. Ness RB, Grisso JA, Cottreau C, Klapper J, Vergona R,Wheeler JE, et al. Factors Related to Inflammation of the Ovarian Epithelium and Risk of Ovarian Cancer. Epidemiology. 2000; 11(2):111-7.
12. Kurman RJ, Carcangiu ML, Harrington CS, Young RH, eds. WHO Classification of Tumors of the Female Reproductive Organs. 4th edition. Geneva, Switzerland: WHO Press; 2014.
13. Fishman DA, Cohen L, Blank SV, Shulman L, Singh D, Bozorgi K et al. The role of ultrasound evaluation in the detection of early stage epithelial ovarian cancer. Am J ObstetGynecol. 2005; 192:1214-21.
14. Kreuzer GF, Parodowski T, Wurche KD, Flenker H. Neoplastic or Nonneoplastic ovarian cyst The Role of Cytology. Acta Cytol. 1995; 39:882-86.
15. Martinez-Onsurbe P, Villaespesa AP, Anquela JMS. Aspiration cytology of 147adnexal cysts with histologic correlation. Acta Cytol. 2001;45:941-47.
16.Kanthikar S.N. et al., Clinico-Pathological Study of Neoplastic and Non-Neoplastic Ovarian Lesion. JCDR. 2014, Vol-8(8): FC04-FC07.
17. Abdullah & Bondagji. Histopathological pattern of ovarian neoplasms and their age distribution in the western region of Saudi Arabia Saudi. Med J. 2012; Vol. 33 (1): 61-65.
18. Ahmad Z, Kayani N, Hasan S, Muzaffar S, Gill M. Histopathological pattern of ovarian neoplasms. J Pak Med Assoc. 2000; 50(12):416-9.
19. Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumors - a study on five years samples. Nepal Med Coll J.2010; 12:221-3.
20. Sharma et al. Pathology of Ovarian Tumour-A Hospital Based Study. Int. j. med. sci. clin. invent .2014; 1(6) :284-286.
21. Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological pattern of neoplastic ovarian lesions. IAIM .2016; 3(1): 51-57.
22. Vinitha Wills & Rachel Mathew. A study on clinico-histopathological patterns of ovarian tumors. Int J Reprod Contracept Obstet Gynecol. 2016; 5(8):2666-2671.
23. Manivasakam J & Arounssalame B. A study of benign adnexal masses. Int J Reprod Contracept Obstet Gynecol. 2012; 1(1):12-6.
24. Huusom LD, Frederiksen K, Hogdall EV, Glud E, Christensen L, Hogdall CK, et al. Association of reproductive factors, oral contraceptive use and selected lifestyle factors with the risk of ovarian borderline tumors: a Danish case- control study. Cancer Causes Control .2006; 17:821-9.
2. Juan Rosai. Female reproductive system-ovary: In: Michael Houston, Joanne Scott editor. Rosai & Ackermann’s Surgical Pathology. 10th ed. Missouri: Elsevier Inc; 2011: 2:1562.
3. Murthy NS, Shalini S, Suman G, Pruthvish S, Mathew A. Changing trends in incidence of ovarian cancer - the Indian scenario. Asian Pac J Cancer Prev .2009; 10:1025-30.
4. Indian Council of Medical Research. Three year report of Population based Cancer Registries: 2012-2014.Bangalore, India: NCDIR-NCRP; 2016.
5. Deligdisch L. Early Diagnosis of Ovarian Cancer. Is It Possible? Med J Obstet Gynecol. 2013; 1: 1003.
6. Lorena Dijmarescu and colab. Diagnosis Correlations in Ovarian Tumors. Current Health Sciences Journal. 2012; 38(1):31-34
7. Takano M, Kikuchi Y, Yaegashi N et al. Clear cell carcinoma of the ovary: a retrospective multicentre experience of 254 patients with complete surgical staging. Br J Cancer. 2006; 94: 1369–1374.
8. du Bois A, Lück HJ, Meier W et al. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst .2003; 95: 1320–1329.
9. Berek JS, Natarajan S. Ovarian and fallopian tube cancer. In: Berek JS editor. Berek & Novak’s gynecology.14th ed. New Delhi: Wolters Kluwer health (India) private limited; 2007: 1457-547.
10. Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST. CT and MR Imaging of Ovarian Tumors with Emphasis on Differential Diagnosis. Radiographics. 2002; 22:1305–25.
11. Ness RB, Grisso JA, Cottreau C, Klapper J, Vergona R,Wheeler JE, et al. Factors Related to Inflammation of the Ovarian Epithelium and Risk of Ovarian Cancer. Epidemiology. 2000; 11(2):111-7.
12. Kurman RJ, Carcangiu ML, Harrington CS, Young RH, eds. WHO Classification of Tumors of the Female Reproductive Organs. 4th edition. Geneva, Switzerland: WHO Press; 2014.
13. Fishman DA, Cohen L, Blank SV, Shulman L, Singh D, Bozorgi K et al. The role of ultrasound evaluation in the detection of early stage epithelial ovarian cancer. Am J ObstetGynecol. 2005; 192:1214-21.
14. Kreuzer GF, Parodowski T, Wurche KD, Flenker H. Neoplastic or Nonneoplastic ovarian cyst The Role of Cytology. Acta Cytol. 1995; 39:882-86.
15. Martinez-Onsurbe P, Villaespesa AP, Anquela JMS. Aspiration cytology of 147adnexal cysts with histologic correlation. Acta Cytol. 2001;45:941-47.
16.Kanthikar S.N. et al., Clinico-Pathological Study of Neoplastic and Non-Neoplastic Ovarian Lesion. JCDR. 2014, Vol-8(8): FC04-FC07.
17. Abdullah & Bondagji. Histopathological pattern of ovarian neoplasms and their age distribution in the western region of Saudi Arabia Saudi. Med J. 2012; Vol. 33 (1): 61-65.
18. Ahmad Z, Kayani N, Hasan S, Muzaffar S, Gill M. Histopathological pattern of ovarian neoplasms. J Pak Med Assoc. 2000; 50(12):416-9.
19. Swamy GG, Satyanarayana N. Clinicopathological analysis of ovarian tumors - a study on five years samples. Nepal Med Coll J.2010; 12:221-3.
20. Sharma et al. Pathology of Ovarian Tumour-A Hospital Based Study. Int. j. med. sci. clin. invent .2014; 1(6) :284-286.
21. Modi D, Rathod GB, Delwadia KN, Goswami HM. Histopathological pattern of neoplastic ovarian lesions. IAIM .2016; 3(1): 51-57.
22. Vinitha Wills & Rachel Mathew. A study on clinico-histopathological patterns of ovarian tumors. Int J Reprod Contracept Obstet Gynecol. 2016; 5(8):2666-2671.
23. Manivasakam J & Arounssalame B. A study of benign adnexal masses. Int J Reprod Contracept Obstet Gynecol. 2012; 1(1):12-6.
24. Huusom LD, Frederiksen K, Hogdall EV, Glud E, Christensen L, Hogdall CK, et al. Association of reproductive factors, oral contraceptive use and selected lifestyle factors with the risk of ovarian borderline tumors: a Danish case- control study. Cancer Causes Control .2006; 17:821-9.
Published
2018-03-01
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