Histopathological Spectrum of Non-Neoplastic Uterine Cervical Lesions in a Tertiary Care Centre
Keywords:
Non-neoplastic, Cervicitis, Endocervix, Histopathology, Hyperplasia
Abstract
Background: Uterine cervix in our routine hysterectomies and biopsies from gynecological specimens constitutes major portal for nonneoplastic lesions. Routine histopathological study of suspicious cases enhances early detection of these uterine cervical lesions.Methods: 250 cases of uterine cervical non-neoplastic lesions were evaluated either from hysterectomy or cervical biopsy specimens. The purpose of this study is to analyze and determine the frequency and histomorphological patterns of non-neoplastic cervical lesions at the tertiary care center and to study various metaplasias of the endocervical epithelium. The cervical lesions were subjected to detailed gross and microscopic examination and further classified into various non-neoplastic lesionsResult: Our study showed that 48 % of cases featured chronic nonspecific cervicitis. The commonest encountered endocervical epithelial lesions were chronic polypoidal endocervicitis (20%) and squamous metaplasia (36%) and the uncommon lesions included micro glandular adenosis (3.2%), endocervical glandular hyperplasia (4%), diffuse laminar endocervical glandular hyperplasia(0.8%) tunnel clusters (0.4%) and mesonephric rests (0.4%). A majority of the ectocervical lesions includes Koilocytic changes, exocytosis, Suprabasal bulla and prolapse changes like hyperkeratosis and parakeratosis. Conclusion: In the present study we emphasized mainly about nonneoplastic uterine cervical lesions among which Chronic non-specific cervicitis is the most confronted lesion in histopathological specimens. However, there are many lesions that appear to be exuberant and can be misdiagnosed to be malignant. On the basis of this, a detailed histomorphological study of the nonneoplastic lesions of the cervix was taken up and further categorized into various lesions which can cause serious morbidities and detailed histopathological study is considered as the gold standard. DOI: 10.21276/APALM.1405References
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2. Reddy SD, Rani MS, Rao KS. Clinico-histopathologic study of nonneoplastic uterine cervical lesions. Int J Med Sci Public Health. 2016: 5(8);1536-1539.
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13. Florescu M, Simionescu C, Georgescu CV, Marinescu M. Histopathologic aspects in microglandular hyperplasia of endocervix. Morphol-Embryol.2004:181–184
14. Simionescu C, Margaritescu CL, Georgescu CV, Mogoanta L, Marinescu AM. Pseudo-tumoral lesions of the cervix. Rom J Morphol Embryol 2005:4;239-47.
15. Medeiros F, Bell DA. Pseudoneoplastic lesions of the female genital tract. Arch Pathol Lab Med. 2010:134(3);393-403.
16. Younis MT, Iram S, Anwar B, Ewies AA. Women with asymptomatic cervical polyps
may not need to see a gynaecologist or have them removed: an observational
retrospective study of 1126 cases. Eur J Obstet Gynecol Reprod Biol. 2010: 150(2):190-4.
17. Ozumba BC, Nzegwu MA, Anyikam A. Histological patterns of gynaecological lesions in Enugu, Nigeria. A five year review. Adv Biores.2011;2:132-36.
18. Nigatu B, Gebrehiwot Y, Kiros K, Eregete W. A five year analysis of histopathological results of cervical biopsies examined in a pathology department of a teaching hospital (2003‑2007). Ethiop J Reprod Health 2010:4;52‑7.
19. Fatima Q, Verma S, Bairwa NK, Gauri LA. Spectrum of Various Lesions in Cervical Biopsies in North West Rajasthan: A Prospective Histopathological Study. Int J Med Res Prof.2017: 3(1); 104-11.
20. Kay J P, Robert A. Current concepts in cervical Pathology. Archives of Pathology & Laboratory Medicine.2009:133; 729-738.
2. Reddy SD, Rani MS, Rao KS. Clinico-histopathologic study of nonneoplastic uterine cervical lesions. Int J Med Sci Public Health. 2016: 5(8);1536-1539.
3. Olutoyin G, Omoniyi-Esan OG, Osasan SA, Ojo OS. Nonneoplastic diseases of the cervix in Nigeria. A histopathological study. Afr Health Sci 2006:6;76-80.
4. Pallipady A, Illanthody S, Vaidya R, Ahmed Z, Suvarna R, Metkar G. A Clinico-Morphological Spectrum of the Non Neoplastic Lesions of the Uterine Cervix at AJ Hospital, Mangalore: Journal of Clinical and Diagnostic Research. 2011:5(3); 546-550.
5. Deepa H, Neha B, Arvind K, Sheela C, Sachan B. Spectrum of Nonneoplastic Lesions of Uterine Cervix in Uttarakhand. National Journal of Laboratory Medicine. 2016;1-5.
6. Richard J, Zaino M.D. Glandular Lesions of the Uterine Cervix: Mod Pathol 2000:13(3);261–274.
7. Jayadeep G, Suman LK, Veena S, Sumit G. Clinicopathological Evaluation of Nonneoplastic and Neoplastic Lesions of Uterine Cervix. Imperial Journal of Interdisciplinary Research (IJIR).2016:2(4).
8. Nwachokor FN, Forae GC. Morphological spectrum of non-neoplastic lesions of the uterine cervix in Warri, Nigeria. Niger J Clin Pract.2013:16(4);429-32.
9. Matos E, Lotia D, Amestoy G, Herrera L, Prince MA, Moreno J, et al. Prevalence of human papillomavirus infection among women in Concordia, Argentina: A population based study. Sex Transm Dis.2003;30;593-9.
10. Jyothi V, Manoja V, Reddy KS. A clinicopathological study on cervix.2015:4(1)3; 2120-2126
11. Nucci MR. Symposium Part III: Tumor-Like Glandular Lesions of the Uterine Cervix. Int J Gynecol Pathol. 2002: 21(4); 347-359.
12. Louis AD, Thomas CK, Joel CW, Christopher MZ, John CE, Mildred RC et.al. Diffuse Laminar Endocervical Glandular Hyperplasia A Case Report. Int J Gynecol Cancer 2009:19;1091-1093.
13. Florescu M, Simionescu C, Georgescu CV, Marinescu M. Histopathologic aspects in microglandular hyperplasia of endocervix. Morphol-Embryol.2004:181–184
14. Simionescu C, Margaritescu CL, Georgescu CV, Mogoanta L, Marinescu AM. Pseudo-tumoral lesions of the cervix. Rom J Morphol Embryol 2005:4;239-47.
15. Medeiros F, Bell DA. Pseudoneoplastic lesions of the female genital tract. Arch Pathol Lab Med. 2010:134(3);393-403.
16. Younis MT, Iram S, Anwar B, Ewies AA. Women with asymptomatic cervical polyps
may not need to see a gynaecologist or have them removed: an observational
retrospective study of 1126 cases. Eur J Obstet Gynecol Reprod Biol. 2010: 150(2):190-4.
17. Ozumba BC, Nzegwu MA, Anyikam A. Histological patterns of gynaecological lesions in Enugu, Nigeria. A five year review. Adv Biores.2011;2:132-36.
18. Nigatu B, Gebrehiwot Y, Kiros K, Eregete W. A five year analysis of histopathological results of cervical biopsies examined in a pathology department of a teaching hospital (2003‑2007). Ethiop J Reprod Health 2010:4;52‑7.
19. Fatima Q, Verma S, Bairwa NK, Gauri LA. Spectrum of Various Lesions in Cervical Biopsies in North West Rajasthan: A Prospective Histopathological Study. Int J Med Res Prof.2017: 3(1); 104-11.
20. Kay J P, Robert A. Current concepts in cervical Pathology. Archives of Pathology & Laboratory Medicine.2009:133; 729-738.
Published
2017-07-05
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